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Moumoujus

GAILLARDIA ARISTATA EXTRACT.

Valuable / BLEACHING, SKIN PROTECTING

Gaillardia Aristata Extract (GAE), derived from the Blanketflower, is a potent botanical ingredient recognized for its advanced depigmenting and antioxidant properties. It precisely targets skin discoloration, offering a comprehensive approach to achieving a brighter, more even complexion.

Summary

Antioxidant Skin-lightening Melanin Inhibition

Science

Mechanism of Action

This extract functions through a multifaceted anti-melanogenic pathway. It actively inhibits melanin production by downregulating the expression of key proteins involved in melanogenesis, including microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), tyrosinase-related protein-1 (TRP-1), and dopachrome tautomerase (DCT). Furthermore, GAE directly suppresses intracellular tyrosinase activity in a dose-dependent manner and demonstrates significant free radical-scavenging capacity and reducing power, contributing to its antioxidant benefits.

Research

Clinical Evidence

Medium confidence
Effective range 10 μg/mL–200 μg/mL%
Optimal

N/A

Key findings

  1. 01 A three-dimensional human skin model study revealed that Gaillardia Aristata Extract (GAE) at a concentration of 200 μg/mL exhibited depigmenting activity comparable to 2% kojic acid, leading to significant skin lightening within 2 weeks. Further in vitro investigations on B16F10 and normal human epidermal melanocytes confirmed a dose-dependent reduction in melanin content and suppression of intracellular tyrosinase activity.

Transparency

Dusting Analysis

Not commonly dusted

Clinical data highlights specific effective concentrations in in vitro and 3D skin models, suggesting that its inclusion would be for targeted efficacy rather than cosmetic dusting at sub-efficacious levels.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While the source plant, Gaillardia aristata, tolerates a broad soil pH range (6.8-9), specific optimal pH conditions for the stability of its cosmetic extract in formulations have not been detailed in current research.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically assessed Gaillardia Aristata Extract. However, a human skin primary irritation test involving 31 subjects reported no adverse skin reactions (erythema, burning, or pruritus) at 30 minutes or 24 hours post-patch removal, indicating a favorable safety profile for topical application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Gaillardia Aristata Extract is a valuable botanical active demonstrating significant depigmenting capabilities comparable to established agents like kojic acid, alongside beneficial antioxidant activity, with a promising safety profile for a wide range of skin types.

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