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Moumoujus

FUMARIA OFFICINALIS LEAF EXTRACT.

Valuable CAS 84625-41-2 / SKIN CONDITIONING

Fumaria Officinalis Leaf Extract is a botanical active renowned for its potent anti-inflammatory and antioxidant properties. Rich in alkaloids and phenolic compounds, it helps soothe skin irritation and offers protection against environmental stressors like ozone.

Summary

Skin conditioning Anti-inflammatory Antioxidant Pollution protection Soothing

Science

Mechanism of Action

This extract exerts its dermatological benefits through a complex array of bioactive compounds, primarily alkaloids such as protopine, stylopine, and allocryptopine, alongside various phenolic compounds including flavonoids. These constituents collectively contribute to its significant anti-inflammatory and antioxidant capacities, notably reducing reactive oxygen species production in skin cells and mitigating inflammatory responses. Furthermore, the presence of fumaric acid enables the extract to neutralize atmospheric ozone, converting it into harmless byproducts and thereby providing a defensive barrier against environmental pollutants.

Research

Clinical Evidence

Medium confidence
Effective range 25–100%
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrated anti-inflammatory activity and a significant reduction of H2O2-induced reactive oxygen species production in keratinocyte models at concentrations of 25, 50, and 100 µg/mL.
  2. 02 A small double-blind clinical trial showed that a Fumaria-infused ointment reduced lesion count and itching in individuals with mild psoriasis.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While in vitro studies indicated an absence of keratinocyte cytotoxicity at concentrations up to 100 µg/mL, a formal safety assessment by regulatory bodies such as CIR or SCCS for topical cosmetic use is currently unavailable. The ingredient has a 'LOW' hazard rating from EWG Skin Deep, although it notes 'Low Availability' of data. Traditional oral use of the plant was rejected from the EU Community List due to lack of toxicology studies for oral consumption, which is distinct from topical application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Fumaria Officinalis Leaf Extract is a valuable botanical ingredient for its established anti-inflammatory and antioxidant benefits, offering soothing effects for irritated skin and environmental protection, despite a current lack of comprehensive regulatory safety review for cosmetic topical applications.

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