Science
Mechanism of Action
This extract functions by modulating abnormal immune responses, thereby mitigating inflammation and reducing swelling in the skin. Its antioxidant capabilities are attributed to polysaccharides, offering protection against oxidative stress. The primary pharmacological activities are believed to stem from its alkaloid content.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies observed antioxidant effects from polysaccharides extracted at a concentration of 1 mg/ml.
- 02 In vivo studies demonstrated that aqueous extracts of FTB inhibited abnormal immune responses, leading to relief of inflammation.
- 03 Alcohol extracts of FTB alleviated xylene and carrageenin-induced ear and foot plantar swelling.
Transparency
Dusting Analysis
Data provided does not suggest Fritillaria Thunbergii Bulb Extract is commonly dusted.
The Formula
Formulation
Safety
Safety Profile
Fritillaria thunbergii Bulbus is traditionally regarded as a low-toxicity herb, yet comprehensive toxicological assessment for topical application is still required. Oral intake studies in rats indicated adverse effects at 3 mg/kg body weight, with a reported median lethal dosage (LD50) in mice varying widely, from 52.2 mg/kg to 12.2 ± 2.2 g/kg. These findings pertain to oral administration and are not directly transferable to topical dermal safety.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Fritillaria Thunbergii Bulb Extract is a valuable botanical for its recognized anti-inflammatory and antioxidant properties and broad skin compatibility, though further dedicated topical studies are needed to determine optimal concentrations and specific skin safety parameters.
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References
Sources