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Moumoujus

FRAXINUS ORNUS SAP EXTRACT.

Valuable CAS 84929-21-5

Fraxinus Ornus Sap Extract, derived from the Manna Ash tree, is a versatile ingredient renowned for its hydrating, antioxidant, and soothing capabilities. Rich in mannitol and flavonoids, it actively shields skin from environmental damage while promoting regeneration and maintaining skin barrier integrity.

Summary

Humectant Antioxidant Soothing Wound Healing Support Anti-inflammatory Antimicrobial Skin Regenerating Anti-elastase Skin Whitening Epidermal Barrier Support

Science

Mechanism of Action

Primarily attributed to its mannitol content, Fraxinus Ornus Sap Extract acts as a potent free radical scavenger, protecting dermal cell membranes and extracellular matrix from reactive oxygen species and UV radiation. It functions as a humectant by attracting and binding water molecules, thereby boosting the skin's moisture retention capacity, which contributes to increased volume, firmness, and elasticity. Mannitol also demonstrates the ability to break down bacterial films, offering potential benefits for acne treatment. Furthermore, the extract contains flavonoids that aid in reducing inflammation and enhancing immune function. Additional noted activities encompass antimicrobial, skin regenerating, anti-elastase, and skin whitening potentials. Preliminary in vitro data suggests it improves epidermal barrier function and stimulates the 5-alpha reductase enzyme, indicating benefits for overall skin nutrition.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a 15-day animal study, a 14.2% bark extract solution demonstrated significantly more intense epithelization of wounds in male rats compared to control groups, suggesting robust wound healing properties.
  2. 02 In vitro cytotoxicity studies confirmed a safe profile for Fraxinus ornus manna extract. When incorporated into a pectin hydrogel, the complex retained approximately 10% of the manna exudate's antioxidant activity. It also exhibited potential as a wound healing agent with antimicrobial and reparative effects on infected tissues, alongside anti-elastase activity and skin whitening potential.
  3. 03 An in vitro evaluation of a new ash tree manna (Fraxinus ornus L.) extract showed improvements in epidermal barrier function, a decrease in inflammation, and stimulation of the 5-alpha reductase enzyme, indicating beneficial results for skin nutrition.
  4. 04 Bark extract demonstrated robust antioxidant activity via the ABTS method, with an IC50 value of 0.062 mg/ml.
  5. 05 Leaves extract exhibited significant antioxidant activity via the DPPH method, with an IC50 value of 0.23 mg/ml.

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest this ingredient is commonly used at ineffective 'dusting' percentages, nor any established dusting threshold.

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 6.8
0 7 14

Stability

A pectin hydrogel formulation containing Fraxinus ornus manna extract successfully preserved the extract's antioxidant activity within a pH range of 5.50 to 6.80, indicating good stability in mildly acidic to neutral conditions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not conducted a specific safety review for Fraxinus Ornus Sap Extract. While comprehensive dermal and oral/parenteral toxicity data are not available, in vitro cytotoxicity studies of the manna extract have indicated a safe biological profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Fraxinus Ornus Sap Extract is a valuable, multi-functional ingredient providing antioxidant protection, enhanced hydration, wound healing support, and soothing benefits for a broad spectrum of skin needs.

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