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Moumoujus

FRAGARIA VESCA LEAF EXTRACT.

Valuable CAS 84929-78-2 / ASTRINGENT, SKIN CONDITIONING

Derived from the wild strawberry leaf, Fragaria Vesca Leaf Extract is a multi-functional botanical ingredient. It provides robust antioxidant protection, helps visibly brighten skin by inhibiting melanin production, and offers soothing anti-inflammatory benefits.

Summary

Astringent Skin Conditioning Antioxidant Antimelanogenic Anti-inflammatory Hydrating Soothing Antiseptic Photoprotective

Science

Mechanism of Action

This extract combats oxidative stress through a rich profile of flavonoids, phenolic acids, ellagitannins, and proanthocyanidins, including protection against UVA-induced free radical damage. Its antimelanogenic action stems from inhibiting tyrosinase, the enzyme crucial for melanin synthesis, partly by quenching copper ions. Tannins contribute to an astringent effect, refining skin texture and minimizing the appearance of pores, while compounds like agrimoniin confer anti-inflammatory benefits against UVB exposure. Saccharides and ellagic acid also provide hydration and soothing properties.

Research

Clinical Evidence

High confidence
Effective range 0.5–2%
Optimal

0.5%

Key findings

  1. 01 When formulated into a hydrogel, it demonstrated antioxidant activity, good cutaneous compatibility, and stability for topical application.
  2. 02 Exhibited significant tyrosinase inhibitory activity, indicating potential for reducing melanin synthesis.
  3. 03 Showed notable photoprotective effects in human dermal fibroblasts, enhancing cell viability in a dose-dependent manner.
  4. 04 An ethanolic extract induced a 31% and 40% inhibition of nitric oxide (NO) decrease, respectively, at non-cytotoxic concentrations, suggesting anti-inflammatory activity.

Transparency

Dusting Analysis

Not commonly dusted

Fragaria Vesca Leaf Extract functions as an active ingredient, with documented efficacy at specific concentrations, rather than serving as a filler.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

A hydrogel formulation remained stable for 28 days under various storage conditions. However, susceptibility to light was observed, leading to browning with sun exposure and darkening with increased fluidity at 40°C. While pH decreased across conditions, it consistently stayed within the skin-compatible range of 4.5-6.5.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

A hydrogel formulation containing 2% (w/w) Fragaria Vesca Leaf Extract demonstrated good skin compatibility in patch tests on 10 volunteers and repeated application tests (HRIPT) on 50 volunteers, showing no irritant reactions. Although the raw extract at a high concentration (2 mg/mL) exhibited cytotoxicity to HaCaT cells, the formulated version did not harm keratinocytes, confirming its suitability for topical use. Closely related Fragaria Vesca Fruit Extract is considered safe with low irritation and sensitization potential, and is not phototoxic. The extract has also been classified as 'safe (Class 1)' with no expected clinically relevant interactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Fragaria Vesca Leaf Extract is a valuable botanical for skincare, offering a range of benefits including antioxidant protection, skin brightening, and soothing effects, making it suitable for various skin types and concerns.

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