FORSYTHIA VIRIDISSIMA FRUIT/(ANGELICA ACUTILOBA/ACTAEA DAHURICA/GLYCYRRHIZA GLABRA/PAEONIA LACTIFLORA/PLATYCODON GRANDIFLORUS/PUERARIA MONTANA) ROOT EXTRACT.

Key findings

1. 01 A 0.2% concentration of matairesinol-rich Forsythia viridissima L. extract clinically demonstrated a significant reduction in skin wrinkles compared to a non-treated control group.
2. 02 Forsythia Suspensa Fruit Extract is broadly recommended at a 2% concentration for its anti-wrinkle, skin whitening, and acne treatment properties.
3. 03 Topical application of 0.5% glabridin, a key component within Glycyrrhiza Glabra Root Extract, was shown to inhibit UVB-induced pigmentation in guinea pigs.
4. 04 Pueraria montana var. lobata ethanol extract, at concentrations between 25-100 μg/mL, dose-dependently increased collagen production and mitigated reactive oxygen species levels in UVB-irradiated human dermal fibroblasts, suggesting potent anti-photoaging activity. For general skincare applications, Pueraria lobata root extract is considered effective at concentrations ranging from 1% to 5%.

Stability

While an optimal pH of 3.94 was observed for the extraction of Forsythia suspensa leaves, the ideal pH range for optimal stability of the entire multi-component extract in a finished product has not been explicitly specified. As with many complex plant extracts, aqueous solubility can sometimes be a consideration, potentially benefiting from specialized formulation techniques.

Conflicts

• Strong acids (can lead to precipitation of glycyrrhizin from licorice components).
• Strong alkalies (may cause precipitation of alkaloids and decomposition of metallic salts).
• Metal salts (general incompatibility noted with many botanical extracts).