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Moumoujus

FILIPENDULA GLABERRIMA EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

Filipendula glaberrima extract demonstrates significant anti-inflammatory and antioxidant properties, primarily by modulating pro-inflammatory pathways and effectively neutralizing free radicals. Its potential extends to soothing skin inflammation and supporting overall skin health.

Summary

Anti-inflammatory Antioxidant Soothing Anti-atopic potential

Science

Mechanism of Action

This extract primarily exerts anti-inflammatory activity by inhibiting key pro-inflammatory mediators such as cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, and interleukin (IL)-6. It also downregulates the phosphorylation of MAPK and NF-κB signaling proteins, crucial pathways in inflammatory responses. Its antioxidant efficacy is attributed to a rich profile of polyphenolic compounds and flavonoids, including (+)-catechin, miquelianin, quercitrin, and afzelin, which effectively neutralize various free radicals.

Research

Clinical Evidence

Medium confidence
Effective range 12.5 µg/mL (in vitro)–50 µg/mL (in vitro)%
Optimal

N/A

Key findings

  1. 01 In vitro studies on lipopolysaccharide-stimulated RAW 264.7 macrophage cells demonstrated dose-dependent anti-inflammatory activity, with up to 71.4% inhibition of nitric oxide (NO) and 74.9% inhibition of IL-6 observed at 50 µg/mL. Cell viability remained over 80% at these concentrations.
  2. 02 In TNF-α + IFN-γ-stimulated HaCaT keratinocyte cells, the extract suppressed the production of pro-inflammatory cytokines (IL-6, IL-8) and chemokines (MCP-1) in a concentration-dependent manner, indicating anti-atopic potential for skin inflammation. Cell viability ranged from 95.3% to 104.6% at the tested concentrations.
  3. 03 Potent antioxidant activities, specifically DPPH and superoxide anion radical-scavenging, were observed with IC50 values as low as 4.07-4.62 µg/mL for specific ethyl acetate and butanol fractions. No cytotoxicity was observed in THP-1 cells at 50 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While in vitro studies consistently reported no cytotoxicity at tested concentrations up to 50 µg/mL, its Cosmetic Ingredient Review (CIR) status is 'not reviewed.' One external source indicates a 'likelihood of irritation' which 'increases when combined with other problematic ingredients' and 'may cause irritation, inflammation, dryness, etc.' Further human safety and irritation potential require comprehensive investigation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Filipendula glaberrima extract demonstrates promising in vitro anti-inflammatory and antioxidant activities, but its comprehensive safety profile and efficacy in human skin require further investigation to meet precision skincare standards.

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