Science
Mechanism of Action
This extract operates through several key mechanisms. It delivers robust antioxidant benefits by neutralizing free radicals, thereby protecting skin from environmental damage. Its anti-inflammatory capabilities contribute to significant skin soothing, while its unique analgesic properties interact with sensory neurons to inhibit two-pore potassium channels, inducing a mild numbing or tingling sensation without causing irritation. This action also enhances skin tolerance and reduces irritation. Furthermore, it exhibits broad-spectrum antibacterial activity against common skin bacteria, and studies suggest it may offer lifting effects and anti-aging benefits through potential hormone regulation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Topical application of 2% Zanthoxylum bungeanum extract (a closely related species) demonstrated a significant short-term reduction in crow's feet wrinkles, indicating its efficacy as a cosmetic agent for temporary wrinkle improvement.
- 02 A Zanthoxylum bungeanum extract (from pericarp, closely related to Fagara zanthoxyloides fruit extract), standardized to contain ≥0.8% Fagaramide and formulated into a body lotion, was highly effective in relieving itchiness in 100% of test subjects. It also significantly improved skin tolerance and inhibited irritation caused by capsaicin.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This extract, alongside its related polyphenols, is notably water-soluble. Its antioxidant activity is particularly robust and stable under acidic conditions, such as a 3% acetic acid system.
Safety
Safety Profile
Zanthoxylum bungeanum fruit extract, a closely related species, is generally regarded as safe for topical cosmetic applications. Acute oral toxicity tests on Fagara zanthoxyloides root-bark extract indicated it was not lethal even at very high dosages (5000 mg/kg body weight), classifying it as 'slightly toxic' but 'relatively safe' for typical oral consumption. Overdoses are primarily associated with self-limiting gastrointestinal discomfort.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Fagara Zanthoxyloides Fruit Extract is a valuable botanical ingredient, offering proven anti-aging, soothing, and protective benefits with excellent skin compatibility across all skin types.
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References
Sources