Science
Mechanism of Action
This extract operates by significantly reducing the production of pro-inflammatory cytokines such as IL-6, TNF-α, and GM-CSF, alongside decreasing hydrogen peroxide levels, thus exerting potent anti-inflammatory effects. Its rich polyphenol and flavonoid content provides robust antioxidant activity by scavenging free radicals. Additionally, it exhibits antiglycation capabilities, helping to protect cellular proteins from sugar-induced damage, and demonstrates notable antimicrobial activity against specific bacteria like E. coli and S. aureus.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies confirmed anti-inflammatory efficacy, notably by reducing hydrogen peroxide production with an IC50 of 43.9 ± 3.8 µg/mL and inhibiting IL-6 production at an IC50 of 73.3 ± 6.9 µg/mL.
- 02 Oral administration in animal models (25-200 mg/kg/day) demonstrated the extract's ability to inhibit secondary inflammatory reactions, delay histopathological alterations, and decrease serum levels of pro-inflammatory cytokines (IL-6, TNF-α, GM-CSF).
- 03 Antioxidant capacity was evidenced in animal studies where a purified extract at 20 mg/kg BW significantly attenuated oxidative damage in the kidneys and liver.
- 04 In vitro antimicrobial testing showed good activity, with a Minimum Inhibitory Concentration (MIC) of 1.56 µg/mL against E. coli and 0.78 µg/mL against S. aureus.
Transparency
Dusting Analysis
No specific data regarding 'dusting' characteristics or thresholds for this ingredient were identified in the available research.
The Formula
Formulation
Stability
While an optimal pH range for cosmetic formulation stability is not explicitly defined, in vitro antioxidant assays have been conducted successfully in phosphate buffers at pH 7.4 or 7.6. The natural pH of Eysenhardtia polystachya heartwood is reported as 5.6.
Safety
Safety Profile
Eysenhardtia Polystachya Wood Extract lacks direct assessment from regulatory bodies such as CIR, SCCS, or FDA. In vivo studies indicated no oral toxicity at tested doses, and low in vitro toxicity was observed, with DNA damage occurring only at concentrations exceeding 200 µg/ml. The SkinSAFE platform, while not a regulatory body, classifies it as 'Teen SAFE', 'Baby SAFE', 'Eyelid SAFE', and 'Irritant Free', suggesting a favorable safety profile for sensitive skin in cosmetic applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eysenhardtia Polystachya Wood Extract is a valuable, multi-functional botanical with scientifically supported anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising ingredient for diverse precision skincare applications.
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References
Sources