Science
Mechanism of Action
This extract exerts its effects through anti-inflammatory and antioxidant pathways, which may help mitigate skin degradation. Its potent antioxidant capacity is partly attributed to high concentrations of superoxide dismutase (SOD). The ingredient contains a spectrum of bioactive compounds, including quassinoids like eurycomanone, canthin-6-one alkaloids, tirucallane triterpenes, squalene derivatives, and various bioactive steroids.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Topical application stimulated angiogenesis and improved Vascular Endothelial Growth Factor (VEGF) expression, supporting wound healing in rats when applied twice daily for 5 days.
- 02 Enhanced the quality of healed skin in rats, likely due to its anti-inflammatory, antioxidant, and antimicrobial attributes.
Transparency
Dusting Analysis
Due to the absence of reported topical concentrations in studies demonstrating efficacy, it is not possible to determine a dusting threshold or assess if this ingredient is commonly used at ineffective concentrations in formulations.
The Formula
Formulation
Stability
Eurycomanone, a key quassinoid within the extract, has demonstrated robust stability at pH 2, pH 5, and pH 6.5, indicating good stability across a broad acidic to slightly acidic pH range relevant for skincare.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not assessed Eurycoma Longifolia Root Extract for topical safety. For oral consumption, it is not recognized as Generally Recognized As Safe (GRAS) by the US FDA, and the EFSA Panel could not establish its safety, noting a potential to induce DNA damage in *in vitro* and *in vivo* studies at high oral doses (2,000 mg/kg body weight). Furthermore, some dietary supplements containing Eurycoma longifolia have been found to be contaminated with heavy metals such as mercury or lead. Clinical data on its topical toxicity is highly limited.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite preliminary evidence from rat studies suggesting topical wound healing and anti-aging benefits, the significant safety concerns, including potential DNA damage identified by the EFSA for oral use and the absence of a CIR safety review for topical application, make Eurycoma Longifolia Root Extract unsuitable for precision skincare formulations.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources