Science
Mechanism of Action
This extract, rich in biochemical compounds such as sesquiterpenes, phenolics, and flavonoids, functions as a potent antioxidant, actively neutralizing free radicals that contribute to skin aging. It exhibits anti-inflammatory and anti-acne properties, assisting in calming skin irritation and reducing blemishes. Its anti-aging efficacy is partly attributed to the preservation of Transforming Growth Factor-β1 (TGF-β1), a crucial factor for collagen synthesis, and its capacity to enhance skin cell proliferation and differentiation, thereby reinforcing the skin's protective barrier.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 A clinical trial involving topical application of 5% stevia gel over 21 days resulted in enhanced skin hydration, brightness, and smoothness, alongside a reduction in fine wrinkles and mild acne.
- 02 An animal study demonstrated that a 5% stevia cream effectively prevented collagen degradation in UVB-exposed skin of male Wistar rats.
- 03 In vitro testing revealed that an aqueous extract at a concentration of 10 mg/mL provided substantial antioxidant activity, showing 60% to 72.37% inhibition in DPPH radical scavenging.
Transparency
Dusting Analysis
No specific data regarding 'dusting' or concentration thresholds for this ingredient were found in the available research.
The Formula
Formulation
Stability
Steviol glycosides, integral components of this extract, generally exhibit pH stability. Optimal stability for impurity adsorption in stevia leaf extracts has been observed within a pH range of 5.5 to 8.0.
Safety
Safety Profile
Topical formulations containing 2.5% and 5% stevia extract have been found safe and non-toxic, with no reported skin irritation in either animal or human studies. The EWG Skin Deep database assigns low concerns for this ingredient regarding cancer, allergies, immunotoxicity, and developmental/reproductive toxicity. However, in vitro studies indicated that ethanolic and glycol-aqueous extracts might be more cytotoxic and irritating than aqueous extracts, possibly due to higher concentrations of certain phytochemicals. Steviol glycosides from Stevia rebaudiana are generally recognized as safe (GRAS) by the FDA for use as sweeteners in food.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eupatorium Rebaudianum Leaf Extract is a valuable, multi-functional botanical offering clinically supported benefits for skin hydration, anti-aging, acne reduction, and robust antioxidant protection, all with a low risk of irritation.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources