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Moumoujus

EUPATORIUM CANNABINUM EXTRACT.

Questionable CAS 84625-34-3 / SKIN CONDITIONING

Eupatorium Cannabinum Extract is a botanical ingredient lauded for its diverse dermatological benefits, encompassing potent antioxidant, anti-inflammatory, and antimicrobial actions. It also supports skin barrier recovery through enhanced wound healing and presents potential anti-hyperpigmentation effects.

Summary

Antioxidant Anti-inflammatory Antimicrobial Antibacterial Wound Healing Anti-acne Anti-tyrosinase Astringent Skin Conditioning

Science

Mechanism of Action

This extract combats oxidative stress by acting as a free radical scavenger and chelating Fe2+ ions. Its anti-inflammatory properties are attributed to the modulation of pro-inflammatory factors and the reduction of inflammatory cytokine production, offering soothing benefits. The ingredient exhibits broad-spectrum antimicrobial activity against common skin microbes, including Propionibacterium acnes and Staphylococcus epidermidis. Furthermore, it supports wound healing by promoting re-epithelialization and enhancing extracellular matrix deposition, and its tannin content provides astringent effects that can aid in reducing swelling. Potential anti-tyrosinase and anti-melanin activities suggest a role in addressing hyperpigmentation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

10%

Transparency

Dusting Analysis

Not commonly dusted

No information regarding common dusting practices or specific thresholds for this ingredient is available in the provided research data.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract's antioxidant activity can be diminished by UVA radiation, necessitating protection from UVA exposure during storage. The characteristics and levels of its active secondary metabolites are highly sensitive to extraction conditions, including pH, temperature, and solvent polarity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While a single-dose animal toxicity test indicated non-toxicity at 125mg/20gw, a significant safety concern for human cosmetic application stems from the Eupatorium genus, including Eupatorium cannabinum, containing pyrrolizidine alkaloids (PAs). PAs are generally recognized as hepatotoxic and genotoxic, necessitating stringent processing to ensure their complete removal or to achieve negligible levels for safe incorporation into cosmetic formulations. Without such assurance, its use presents considerable risk.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite promising preclinical data for broad dermatological benefits, the unreviewed safety status and the documented presence of hepatotoxic pyrrolizidine alkaloids render this ingredient highly questionable for precision skincare without verified absence or extremely low levels of these hazardous compounds.

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