Science
Mechanism of Action
This extract functions through multiple pathways, displaying significant antioxidant activity by neutralizing DPPH radicals, moderate anti-inflammatory effects by inhibiting nitric oxide production in cells, and anti-melanogenesis capabilities, specifically targeting melanin formation. Its broad-spectrum antimicrobial properties contribute to skin purification and protection, while its reparative and anti-aging potential promotes cellular renewal, enhancing skin elasticity and firmness.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Inhibited melanin formation in B16 melanoma cells (IC50) at a concentration of 1780 μM (of 7-methoxycoumarin), demonstrating antimelanogenesis activity.
- 02 Exhibited antioxidant activity with a half inhibition concentration (IC50) of 22.7 µg/ml (EtOAc extract) against DPPH radicals.
- 03 Demonstrated moderate anti-inflammatory activity, inhibiting nitric oxide in RAW264.7 cells with IC50 values of 65.7 µg/ml (CH2Cl2 extract) and 66.9 µg/ml (EtOAc extract).
- 04 Showed antimicrobial efficacy against various bacteria: 62 µg/ml (methanol extract) for Enterococcus faecalis, 75 µg/ml (methanol extract) for Staphylococcus aureus, and a range of 16 to 125 µg/ml (non-polar fractions) against Gram-negative bacteria, primarily E. coli. Protein extracts at 0.4 - 200 µg/ml also displayed activity against E. coli, Staphylococcus aureus, Streptococcus species, and MRSA strains.
Transparency
Dusting Analysis
Insufficient data available to determine common dusting practices or thresholds for this ingredient.
The Formula
Formulation
Stability
The active compounds within Eupatorium Ayapana Extract can be extracted using a variety of solvents, including polar (water, methanol, ethanol) and non-polar (petroleum ether, chloroform, ethyl acetate), suggesting solubility across different solvent systems. Protein components have been shown to be fully soluble in Tris-Cl (pH 7.4) buffer.
Safety
Safety Profile
No adverse effects have been reported with the traditional use of Ayapana. It is formally recognized in the French Pharmacopeia. Specific cosmetic safety data regarding maximum concentration or sensitization risk for topical application are not comprehensively reviewed by CIR.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eupatorium Ayapana Extract is a valuable botanical offering diverse benefits, including antioxidant, anti-inflammatory, and antimicrobial properties, making it a robust addition to advanced skincare formulations.
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References
Sources