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Moumoujus

EUGENIA UNIFLORA LEAF POWDER.

Valuable CAS - / ABRASIVE

Derived from the pitanga leaf, Eugenia Uniflora Leaf Powder delivers multifaceted benefits to the skin. Rich in phenolic compounds and tannins, it acts as a potent antioxidant, defends against microbial threats, and provides significant anti-inflammatory and astringent properties.

Summary

Antioxidant Antibacterial Antimicrobial Anti-inflammatory Astringent Skin conditioning Anti-aging (via anti-elastase activity)

Science

Mechanism of Action

This ingredient operates through several sophisticated pathways to enhance skin health. It neutralizes reactive oxygen and nitrogen species via a hydrogen atom transfer mechanism, conferring robust antioxidant protection. Its antibacterial and antimicrobial actions stem from damaging bacterial cell membranes, inhibiting nucleic acid synthesis, and disrupting ATP synthase. Furthermore, it modulates inflammatory responses by reducing pro-inflammatory cytokines (IL-1β, TNF-α), decreasing iNOS and COX-2 expression, and limiting leukocyte migration, while also exhibiting anti-elastase activity for potential anti-aging effects and an astringent action to tighten skin.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated potent antibacterial activity against multidrug-resistant bacteria, with crude extracts showing efficacy between 125-1000 µg/mL and ethyl acetate fractions between 7.81-500 µg/mL.
  2. 02 Exhibited significant antioxidant activity, measured by DPPH• radical scavenging, with an IC50 of 1.46 µg/mL for the ethyl acetate fraction and 9.50 µg/mL for glycolic extracts.
  3. 03 Showed fungicidal properties from glycolic extracts at a concentration of 3.9 µg/mL.
  4. 04 When formulated in a film-forming system at 7.81%, it maintained antimicrobial and antioxidant efficacy, achieving Minimum Inhibitory Concentrations (MIC) of 12.5 mg/mL against Staphylococcus aureus, 15.0 mg/mL against Escherichia coli, and 17.5 mg/mL against Candida albicans.
  5. 05 An aqueous extract significantly reduced inflammatory markers including leukocyte migration, myeloperoxidase activity, and levels of pro-inflammatory cytokines (IL-1β and TNF-α), confirming anti-inflammatory effects.

Transparency

Dusting Analysis

Not commonly dusted

Data regarding specific dusting characteristics or thresholds for Eugenia Uniflora Leaf Powder are not available within the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH 4.37 – 5.3
0 7 14

Stability

Optimal stability and suitability for topical application are observed in formulations within a pH range of 4.37 to 5.3. Effective extraction of its beneficial polyphenols is achieved using polar solvents like water, ethanol, and propylene glycol.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Aqueous extracts of Eugenia uniflora leaves have demonstrated non-toxic and non-genotoxic effects in vivo at acute doses up to 2000 mg/kg and subacute doses up to 1000 mg/kg over 28 days, indicating a substantial safety margin for general use. Glycolic extracts also exhibit low toxicity. The ingredient, as 'Eugenia Uniflora Leaf Extract,' is identified as 'Irritant Free' by SkinSAFE.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Eugenia Uniflora Leaf Powder is a valuable ingredient, offering broad-spectrum benefits including potent antioxidant, anti-inflammatory, antimicrobial, and astringent properties, suitable for diverse skin types with a low irritation risk.

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