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EUGENIA UNIFLORA LEAF OIL.

Valuable CAS - / ANTIMICROBIAL

Eugenia Uniflora Leaf Oil is an essential oil extracted from the Surinam cherry plant, recognized for its potent antimicrobial and antioxidant capabilities. It operates by disrupting microbial membranes and scavenging free radicals, making it a multifaceted ingredient for targeted skin concerns. Its efficacy is observed at remarkably low concentrations across various biological activities.

Summary

Antimicrobial Antioxidant Anti-inflammatory (potential) Preservative (potential)

Science

Mechanism of Action

The antimicrobial action of Eugenia Uniflora Leaf Oil, primarily attributed to compounds like curzerene, is believed to involve the disruption of microbial membrane integrity, leading to cell demise. Its antioxidant capacity functions predominantly via single electron transfer. Furthermore, the leaf's inherent flavonoids may offer anti-inflammatory benefits by acting as a defense mechanism against various stressors. Anti-Leishmania activity may involve macrophage activation.

Research

Clinical Evidence

Medium confidence
Effective range 0.00081–0.122%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.00081%

Effective concentrations for Eugenia Uniflora Leaf Oil are notably low, with antioxidant activity observed at 0.00081% (IC50) and antimicrobial effects starting from 0.0208% (MIC). These low thresholds suggest that high concentrations are not required to achieve its biological benefits, reducing the likelihood of 'dusting' in formulations.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As a lipophilic essential oil, it exhibits poor water solubility. Its stability and bioavailability can be significantly improved by incorporating it into nanoemulsion systems, which also serve to protect its active compounds from degradation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Acute oral administration in mice at doses exceeding 200 mg/kg demonstrated no lethality or toxicological effects, indicating a low toxicity profile at these levels. Aqueous extracts of the leaves have also been reported as non-toxic and non-genotoxic in vivo. While high concentrations (400 µg/mL) showed some cytotoxicity with 63.22% hemolytic activity, no toxicity was observed at 50 µg/mL. Comprehensive CIR, SCCS, or FDA safety evaluations for the oil are currently unavailable.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Eugenia Uniflora Leaf Oil is a valuable active ingredient for precision skincare due to its significant antimicrobial and antioxidant properties, effective at low concentrations, though further human skin-specific safety and efficacy data would enhance its profile.

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