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ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE.

Essential CAS 81065-76-1 / ANTIOXIDANT

ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE, also known as EUK-134, is a powerful synthetic antioxidant engineered to mimic the skin's natural superoxide dismutase (SOD) and catalase enzymes. It actively neutralizes damaging free radicals and reactive oxygen species, providing broad-spectrum protection against environmental stressors and supporting cellular health.

Summary

Antioxidant Photo-protection Anti-aging Anti-inflammatory DNA protection ECM preservation Redness reduction

Science

Mechanism of Action

This self-regenerating synthetic molecule operates by efficiently dismutating superoxide anions and neutralizing hydrogen peroxide (H2O2), converting these reactive oxygen species into harmless water and oxygen. By mimicking natural antioxidant enzymes, EUK-134 significantly reduces oxidative stress on the skin, protecting against free radical damage, DNA damage, and reducing erythema. It also plays a role in preventing premature aging and photoaging by inhibiting MMP-2, which helps preserve the extracellular matrix (ECM) network. Furthermore, it protects cells from UVB-induced oxidative damage, mitigating MAPK signaling and p53 accumulation, thereby increasing cell survival after UVB irradiation.

Research

Clinical Evidence

High confidence
Effective range 0.01–0.1%
Optimal

0.1%

Key findings

  1. 01 Clinical studies involving human volunteers demonstrated that concentrations between 0.01% and 0.1% reduced skin surface lipid peroxidation in UVA-exposed skin, even when applied after exposure.
  2. 02 In vivo applications lowered hydroperoxide levels on the surface of UVA-exposed skin.
  3. 03 A 0.1% concentration was shown to protect cells from UVB damage, reduce oxidative stress-induced MAPK signaling, decrease p53 induction, and significantly enhance cell survival following UVB irradiation.
  4. 04 Formulations at 0.1% support the skin's defense against environmental stressors and are well-tolerated by various skin types, including sensitive skin.

Transparency

Dusting Analysis

Not commonly dusted

Given its potent efficacy at concentrations as low as 0.01%, ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE is typically included at functional percentages to deliver significant benefits and is not commonly associated with ingredient dusting.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

EUK-134 maintains optimal stability within a pH range of 6.0 to 8.0. However, the presence of water can impair its stability, which is why many high-efficacy formulations utilize anhydrous (water-free) bases to preserve its potency.

Conflicts

  • Highly acidic formulations (e.g., direct Vitamin C suspensions)
  • Copper Peptides
  • Direct Acids (e.g., AHAs, BHAs)
  • Resveratrol and Ferulic Acid

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While formal CIR, SCCS, or FDA review status is not explicitly documented, products containing EUK-134 at 0.1% are widely available and marketed. SkinSAFE considers these formulations hypoallergenic and free from many common allergy-causing ingredients, suggesting a favorable safety profile in practical cosmetic applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Essential

ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE is an essential, biomimetic antioxidant providing broad-spectrum protection against environmental damage, supporting cellular resilience and maintaining overall skin integrity across all skin types.

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