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Moumoujus

ETHYL UROCANATE.

Avoid CAS 27538-35-8 / SKIN CONDITIONING, UV ABSORBER

Ethyl Urocanate is the ethyl ester of Urocanic Acid (UCA), a natural moisturizing factor and endogenous photoprotectant found in the skin's stratum corneum. Despite its parent compound's inherent biological roles, Ethyl Urocanate is unequivocally prohibited for use in cosmetic products across major regulatory regions, including the European Union, Canada, and Singapore.

Summary

Science

Mechanism of Action

As the ethyl ester of Urocanic Acid (UCA), Ethyl Urocanate is chemically related to a compound naturally present within the skin's stratum corneum. UCA actively functions as a natural moisturizing factor and inherently protects against UV radiation, particularly in the UV-C and UV-B spectrums, thereby mitigating UVB-induced DNA damage. Upon UVB exposure, trans-Urocanic Acid undergoes isomerization to cis-Urocanic Acid, which exhibits immunomodulatory properties. However, specific direct mechanisms of action for Ethyl Urocanate as a topical skincare ingredient are not established due to its regulatory prohibition in cosmetics.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Ethyl Urocanate is a prohibited substance in cosmetic formulations across multiple major regulatory bodies, rendering its use in commercial products impossible and thus, the concept of 'dusting' irrelevant for this ingredient.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The precise optimal pH range for Ethyl Urocanate's stability is not explicitly detailed. For its parent compound, Urocanic Acid, UV absorption characteristics are known to be sensitive to the solvent's pH and polarity. General chemical handling guidelines recommend storage away from strong oxidizing agents and bases.

Conflicts

  • strong oxidizing agents
  • bases
  • reducing agents

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
0%
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel deemed data insufficient to conclude on the safety of Urocanic Acid, the parent compound. Ethyl Urocanate, along with Urocanic Acid, is explicitly listed in Annex II (entry II/418) of the EU Cosmetics Regulation, meaning it is a prohibited substance for cosmetic applications in the European Union. Health Canada and Singapore also enforce similar prohibitions on its use in personal care products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its explicit prohibition in cosmetic products by major regulatory bodies globally, Ethyl Urocanate is unequivocally unsuitable for skincare formulations and must be avoided.

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