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ETHYL MENTHANE CARBOXAMIDE.

Valuable CAS 39711-79-0 / TONIC

Ethyl Menthane Carboxamide is a synthetic, non-volatile menthol derivative engineered to deliver a sustained and gentle cooling sensation to the skin. It acts as a refreshing and soothing agent without the intense pungency often associated with menthol.

Cooling Agent Refreshing Agent Soothing Agent Tonic

Science

This ingredient functions by selectively engaging temperature-sensitive TRPM8 receptors in the skin, which are responsible for perceiving cold. Unlike menthol, it is virtually odorless, tasteless, and non-volatile, resulting in a milder, longer-lasting cooling effect. It may also contribute to skin soothing, anti-itching properties, and improved skin penetration.


Research

Medium confidence
Effective range 0.05–0.2%
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Ethyl Menthane Carboxamide exhibits excellent chemical stability and low volatility, ensuring its consistent performance within various cosmetic formulations. It maintains its integrity at a neutral pH.

Synergies

  • Menthyl Lactate
  • Menthyl PCA

Conflicts

  • strong acids
  • strong oxidizing agents
  • strong bases

Safety

CIR Status
Not reviewed
Sensitization risk Low

Generally regarded as safe for use in cosmetic formulations, Ethyl Menthane Carboxamide is classified by the US FDA as safe for general or specific limited use in food. The EWG Skin Deep database assigns it low concern ratings for cancer, allergies & immunotoxicity, developmental and reproductive toxicity. However, in its concentrated raw form, the material safety data sheet indicates potential for eye, skin, and respiratory tract irritation, and harm if swallowed, risks significantly mitigated in cosmetic dilutions.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Ethyl Menthane Carboxamide is a valuable cooling agent, offering a long-lasting and gentle sensation of freshness with broad skin compatibility and low irritation potential, making it ideal for precision skincare formulations.


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