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Moumoujus

ETHYL HEXANOATE.

Optional CAS 123-66-0 / PERFUMING

Ethyl Hexanoate is an ester ingredient primarily utilized for its emollient properties in skincare formulations. It contributes to improved skin hydration by forming a protective film, thereby helping to reduce moisture loss and defend against environmental stressors. Additionally, it functions as a solvent and fragrance component.

Summary

Emollient Fragrance Ingredient Solvent

Science

Mechanism of Action

As an ester, Ethyl Hexanoate forms a thin, non-occlusive film on the skin's surface. This action is similar to other alkyl ethylhexanoates, effectively reducing transepidermal water loss and preventing dehydration. The resulting barrier improves skin hydration and enhances the spreadability and textural properties of skincare formulations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Ethyl Hexanoate is poorly soluble in water (approximately 0.06 g/100 mL at 25 °C) and propylene glycol, but demonstrates miscibility with ethanol, ether, and most organic oils. As an ester, it is susceptible to hydrolysis, particularly when exposed to extreme pH values.

Synergies

  • Enhances the spreadability and absorption of other ingredients in formulations.

Conflicts

  • Formulations containing alkyl ethylhexanoates must be designed to be non-irritating.
  • Caution is advised when combining Ethyl Hexanoate with ingredients whose safety relies on limited dermal absorption, as it can enhance skin penetration.
  • Specific incompatibilities noted for related esters include Salicylic acid, Polymethylsilsesquioxane, Alpha Arbutin, and Butylene Glycol Dicaprylate.

Safety

Safety Profile

CIR Status
Safe as used with restrictions
Max tested
52%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Ethyl Hexanoate, as part of the alkyl ethylhexanoate group, is safe for use in cosmetic formulations under current practices and concentrations, provided the final product is non-irritating. The Expert Panel for Fragrance Safety (RIFM) considers it safe as a fragrance ingredient, with a No Expected Sensitization Induction Level (NESIL) of 4700 μg/cm2 for skin sensitization, and no anticipated phototoxic or photoallergenic effects. The FDA recognizes it as a flavoring agent.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Ethyl Hexanoate offers valuable emollient benefits and can enhance product aesthetics and texture, making it an optional addition for specific formulation goals within precision skincare.

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