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ETHYL CARBAZIDO HYALURONATE SH-OLIGOPEPTIDE-1 SH-POLYPEPTIDE-94 DIPEPTIDE-35 SH-POLYPEPTIDE-94 SH-POLYPEPTIDE-95.

Valuable / SKIN PROTECTING

This sophisticated complex combines a hyaluronic acid derivative with a blend of synthetic fusion peptides, including the well-researched SH-Oligopeptide-1. It is engineered to deliver comprehensive hydration, promote cellular regeneration, and enhance the skin's structural integrity for a visibly revitalized and smoother appearance, addressing multiple signs of aging.

skin protecting anti-aging anti-wrinkle skin regenerating skin repairing hydrating brightening smoothing collagen boosting elastin boosting moisturizing

Science

This ingredient is a complex formulation integrating Ethyl Carbazido Hyaluronate, a hyaluronic acid derivative, with several synthetic fusion peptides. Ethyl Carbazido Hyaluronate primarily acts as a humectant, attracting and retaining moisture to provide essential skin hydration. SH-Oligopeptide-1 (Epidermal Growth Factor, EGF) is a crucial cellular signaling molecule that accelerates skin repair by stimulating the proliferation of epidermal cells, including keratinocytes, endothelial cells, and fibroblasts. It also enhances blood vessel formation, stimulates the secretion of rejuvenating growth factors, and boosts the synthesis of vital extracellular matrix components like collagen, elastin, and glycosaminoglycans, contributing to long-term moisturization. SH-Polypeptide-1 (Basic Fibroblast Growth Factor, bFGF), another component, specifically promotes fibroblast cell growth, proliferation, and the synthesis of collagen and other extracellular matrix elements. The precise mechanisms of SH-Polypeptide-94, Dipeptide-35, and SH-Polypeptide-95 within this specific complex are less detailed in available research, but as peptides and growth factors, they are expected to contribute synergistically to cell signaling, proliferation, and extracellular matrix production.


Research

Medium confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

SH-Oligopeptide-1, a key component, exhibits sensitivity to pH fluctuations and is prone to microbial contamination. For optimal formulation stability, the pH of the base product should be adjusted to between 5 and 8 before incorporating the diluted SH-Oligopeptide-1 solution. This peptide should be added as the final step of the formulation process, at temperatures maintained below 45℃. Despite these sensitivities, SH-Oligopeptide-1, particularly in certain commercial forms (e.g., SpecBio™EGF Plus (CE85)), has demonstrated good stability at room temperature.


Safety

CIR Status
Not reviewed
Sensitization risk Unknown

The comprehensive complex, ETHYL CARBAZIDO HYALURONATE SH-OLIGOPEPTIDE-1 SH-POLYPEPTIDE-94 DIPEPTIDE-35 SH-POLYPEPTIDE-94 SH-POLYPEPTIDE-95, has not undergone specific safety reviews by major regulatory bodies such as CIR, SCCS, or FDA. While SH-Oligopeptide-1 is authorized for generalized cosmetic use across various concentrations, its long-term risks remain undefined, and there are ongoing discussions regarding its appropriate classification as a cosmetic versus a drug. Individually, SkinSAFE rates SH-Oligopeptide-1 as 'Teen SAFE,' 'Baby SAFE,' and 'Eyelid SAFE,' also categorizing it as 'Irritant Free,' indicating a low individual risk for irritation or sensitization.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

This complex combines effective hydration with potent growth factor-mediated skin rejuvenation, making it a valuable asset for advanced anti-aging and reparative skincare despite some scientific discourse on its long-term profile as a full complex.


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