Science
Mechanism of Action
This ingredient is a complex formulation integrating Ethyl Carbazido Hyaluronate, a hyaluronic acid derivative, with several synthetic fusion peptides. Ethyl Carbazido Hyaluronate primarily acts as a humectant, attracting and retaining moisture to provide essential skin hydration. SH-Oligopeptide-1 (Epidermal Growth Factor, EGF) is a crucial cellular signaling molecule that accelerates skin repair by stimulating the proliferation of epidermal cells, including keratinocytes, endothelial cells, and fibroblasts. It also enhances blood vessel formation, stimulates the secretion of rejuvenating growth factors, and boosts the synthesis of vital extracellular matrix components like collagen, elastin, and glycosaminoglycans, contributing to long-term moisturization. SH-Polypeptide-1 (Basic Fibroblast Growth Factor, bFGF), another component, specifically promotes fibroblast cell growth, proliferation, and the synthesis of collagen and other extracellular matrix elements. The precise mechanisms of SH-Polypeptide-94, Dipeptide-35, and SH-Polypeptide-95 within this specific complex are less detailed in available research, but as peptides and growth factors, they are expected to contribute synergistically to cell signaling, proliferation, and extracellular matrix production.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
SH-Oligopeptide-1, a key component, exhibits sensitivity to pH fluctuations and is prone to microbial contamination. For optimal formulation stability, the pH of the base product should be adjusted to between 5 and 8 before incorporating the diluted SH-Oligopeptide-1 solution. This peptide should be added as the final step of the formulation process, at temperatures maintained below 45℃. Despite these sensitivities, SH-Oligopeptide-1, particularly in certain commercial forms (e.g., SpecBio™EGF Plus (CE85)), has demonstrated good stability at room temperature.
Safety
Safety Profile
The comprehensive complex, ETHYL CARBAZIDO HYALURONATE SH-OLIGOPEPTIDE-1 SH-POLYPEPTIDE-94 DIPEPTIDE-35 SH-POLYPEPTIDE-94 SH-POLYPEPTIDE-95, has not undergone specific safety reviews by major regulatory bodies such as CIR, SCCS, or FDA. While SH-Oligopeptide-1 is authorized for generalized cosmetic use across various concentrations, its long-term risks remain undefined, and there are ongoing discussions regarding its appropriate classification as a cosmetic versus a drug. Individually, SkinSAFE rates SH-Oligopeptide-1 as 'Teen SAFE,' 'Baby SAFE,' and 'Eyelid SAFE,' also categorizing it as 'Irritant Free,' indicating a low individual risk for irritation or sensitization.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This complex combines effective hydration with potent growth factor-mediated skin rejuvenation, making it a valuable asset for advanced anti-aging and reparative skincare despite some scientific discourse on its long-term profile as a full complex.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources