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ETHYL BUTYLACETYLAMINOPROPIONATE.

Valuable CAS 52304-36-6 / SKIN CONDITIONING, SURFACTANT - CLEANSING

Ethyl Butylacetylaminopropionate, also known as IR3535, is a synthetic insect repellent widely recognized for its efficacy against mosquitoes, ticks, and biting flies. It functions by disrupting insect olfactory systems, providing a safe and effective method to mask human attractants without being toxic to insects.

Summary

Insect Repellent Skin Conditioning Surfactant

Science

Mechanism of Action

This compound primarily operates by interfering with the olfactory receptor neurons (ORNs) in insects. By disrupting these receptors, Ethyl Butylacetylaminopropionate prevents pests from accurately detecting natural human attractants like carbon dioxide and lactic acid, essentially rendering the host undetectable. Its action is non-toxic, repelling insects rather than eliminating them.

Research

Clinical Evidence

High confidence
Effective range 10–30%
Optimal

20%

Key findings

  1. 01 A 20% concentration, particularly in sustained-release formulations, demonstrated repellency against mosquitoes (e.g., Aedes, Culex) nearly identical to DEET and picaridin, with protection lasting up to 9 hours in field studies. Laboratory tests showed protection durations of 9.8 hours against Aedes aegypti, 13.7 hours against Culex quinquefasciatus, and 14.8 hours against C. tritaeniorhynchus.
  2. 02 A 10% concentration provided over 7 hours of protection against various pests with a single application.
  3. 03 Concentrations below 10% typically result in diminished repellent effects, often lasting less than 30 minutes.

Transparency

Dusting Analysis

Not commonly dusted

Ethyl Butylacetylaminopropionate (IR3535) is a well-established active ingredient with extensive research and regulatory approvals as an insect repellent. Its use is based on proven efficacy rather than unsubstantiated claims, making it unlikely to be subject to 'dusting' concerns.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 6
0 7 14

Stability

Optimal stability in aqueous solutions is achieved within a pH range of 4.0 to 6.0. Formulations should avoid temperatures exceeding 40°C. Degradation by sunlight necessitates consideration for reapplication frequency in sun-exposed products.

Conflicts

  • Strong oxidizing agents can compromise its stability.
  • It may dissolve certain plastics and synthetic fabrics; polyethylene and polypropylene are generally compatible.
  • When using carbomers in aqueous phases, they must be neutralized to a pH of 6 or higher before combining with Ethyl Butylacetylaminopropionate.
  • Minimizing water content in formulations is crucial for optimal stability.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
20%
Pregnancy
Safe
Sensitization risk Low

IR3535 exhibits a favorable toxicological profile with low mammalian toxicity and reduced irritation compared to DEET. Classified as a biochemical by the EPA in 1997 and registered in 1999, the WHO confirmed its safety and efficacy for personal use in 2001. It is considered safe for use in children from 6 months of age (with some sources suggesting 2 months or 1 year) and for pregnant and breastfeeding individuals, showing minimal risk of irritation or neurotoxicity at recommended concentrations. However, direct contact with eyes can cause serious irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Ethyl Butylacetylaminopropionate is a highly valuable ingredient due to its proven broad-spectrum insect repellent efficacy, favorable safety profile for sensitive populations, and compatibility across all skin types.

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