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ETHYL AZELAIC ACID/PROPANEDIOL COPOLYMER.

Insufficient Data / PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT, VISCOSITY CONTROLLING

ETHYL AZELAIC ACID/PROPANEDIOL COPOLYMER is an innovative copolymer designed to enhance the delivery and stability of azelaic acid. It optimizes the efficacy of azelaic acid, a known active, by improving its solubility and permeation into the skin, thereby maximizing its multifaceted benefits for complexion clarity and evenness.

Summary

Plasticizer Skin conditioning Emollient Solvent Viscosity controlling

Science

Mechanism of Action

The primary mechanism of action for this copolymer on the skin is attributed to its azelaic acid component. Azelaic acid targets Propionibacterium acnes, reducing bacterial proliferation. It normalizes disturbed follicular keratinization, preventing the formation of comedones. Furthermore, it exerts anti-inflammatory properties that reduce redness, swelling, and irritation. As a tyrosinase inhibitor, it effectively diminishes hyperpigmentation, such as sun damage and post-inflammatory marks, and its ability to reduce reactive oxygen species further contributes to its anti-inflammatory and antimelanogenic effects.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 5
0 7 14

Stability

The propanediol component significantly aids in solubilizing and stabilizing azelaic acid within formulations. While azelaic acid has limited water solubility (approximately 2.1-2.4 g/L at 20°C) and negligible solubility in cosmetic oils, it exhibits high solubility in glycols like propanediol. This ensures the azelaic acid remains in a stable, solubilized state. Formulations are generally most stable and skin-compatible within a pH range of 4.0-5.0.

Synergies

  • Propanediol component for enhanced azelaic acid solubility and stability

Conflicts

  • Ethyl alcohol (can destabilize azelaic acid, reducing efficacy)
  • Formulations with pH below 4.0 (potential for skin irritation)
  • Strong acidic conditions (may regenerate azelaic acid, leading to crystallization if not managed)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Specific Cosmetic Ingredient Review (CIR) safety data for ETHYL AZELAIC ACID/PROPANEDIOL COPOLYMER is currently unavailable. General 'Acrylates Copolymers' are considered safe in cosmetics when properly formulated to prevent irritation. Azelaic acid, the active component, is broadly recognized as safe for topical use, with FDA approval for 15% and 20% concentrations in pharmaceutical applications.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While the core azelaic acid component offers significant benefits for skin clarity and evenness, specific safety and clinical efficacy data for this copolymer are currently insufficient, warranting further investigation for a complete assessment.

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