Science
Mechanism of Action
This extract functions as a free radical scavenger and chelates transition metal ions, providing robust antioxidant protection. Its anti-inflammatory action involves inhibiting pro-inflammatory mediators such as TNF-α, COX2, and the TLR4/NLRP3 inflammasome, while simultaneously restoring anti-inflammatory cytokine IL-10 expression. Key flavonoid components, including quercetin and isorhamnetin, enhance skin barrier function by activating peroxisome proliferator-activated receptor (PPAR)-α and promoting filaggrin expression. Furthermore, it demonstrates anti-melanogenic activity by directly inhibiting tyrosinase and suppressing its intracellular production, leading to a reduction in melanin content. The extract also possesses antimicrobial properties against various bacterial and fungal species.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies on NSC-34 motor neurons demonstrated that Eruca Sativa Seed Extract at 0.3 µg/ml effectively prevented LPS-induced morphological changes, inhibited TNF-α, COX2, and TLR4/NLRP3 inflammasome expression, counteracted apoptosis, and restored IL-10 expression, indicating significant anti-inflammatory and neuroprotective effects.
- 02 In murine melanoma B16F10 cells, the extract exhibited low cytotoxicity at concentrations below 100 mg/L. It inhibited tyrosinase activity (ID50: 132.54 mg/L) and decreased melanin content (ID50: 158.90 mg/L) in a concentration-dependent manner, confirming an anti-melanogenic effect.
- 03 Research indicates that Eruca Sativa extract and its flavonoid components (quercetin and isorhamnetin) activate PPAR-α and suppress inflammatory cytokines, promoting filaggrin expression, which improves skin barrier function relevant for conditions like atopic dermatitis.
Transparency
Dusting Analysis
There is no available data to indicate Eruca Sativa Seed Extract is commonly 'dusted' in cosmetic formulations, nor are specific dusting thresholds or red-flag percentages identified.
The Formula
Formulation
Stability
Glucosinolate (GSL) content in oil-free, GSL-enriched Eruca Sativa extracts has shown stability for approximately 12 months when stored at -20 °C. Optimal pH for mucilage extraction (4) is not directly indicative of extract stability in final cosmetic formulations.
Synergies
- Flavonoid components (quercetin, isorhamnetin) enhance barrier function and anti-inflammatory effects.
Safety
Safety Profile
No specific safety assessments or established maximum concentrations for cosmetic use by CIR, SCCS, or FDA were found. In one in-vitro study, moderate cytotoxicity was observed at 0.4 µg/ml in NSC-34 motor neurons, although lower concentrations (0.1-0.3 µg/ml) showed no cytotoxicity in the same model. Information regarding sensitization potential or pregnancy safety is not available in the provided data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eruca Sativa Seed Extract presents as a valuable ingredient with robust in-vitro evidence for antioxidant, anti-inflammatory, barrier-support, and anti-melanogenic effects, though further in-vivo studies and comprehensive safety assessments are needed for precise topical application guidelines.
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References
Sources