Science
Mechanism of Action
This extract functions as a potent antioxidant, neutralizing oxidative stress through its abundance of phenolic acids and flavonoids. Its anti-inflammatory capabilities stem from triterpenes and vitamins, which calm skin responses by inhibiting inflammatory mediators like iNOS, COX-2, nitric oxide, and TNF-α, partly by downregulating NF-κB activation and MAPK phosphorylation. It also attenuates NF-κB, p38 MAPK, and ERK in mast cells. Furthermore, it demonstrates antimicrobial efficacy, suppresses melanin synthesis by inhibiting melanogenesis in B16 melanoma cells and tyrosinase activity, and contributes to anti-aging by hindering collagenase and hyaluronidase enzymes, thereby preserving skin collagen and hyaluronic acid to promote softness and suppleness. Key compounds like ursolic acid, maslinic acid, pomolic acid, and corosolic acid are identified for these specific actions, including stimulating new collagen and hyaluronic acid production.
Research
Clinical Evidence
High confidence0.5% (w/v) ethanol extract
Key findings
- 01 Significantly reduced LPS-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) levels in RAW 264.7 cells, demonstrating anti-inflammatory activity. Concurrently, it markedly inhibited melanogenesis in melanocyte stimulating hormone-induced B16F1 cells.
- 02 Stimulated approximately 52% procollagen synthesis activity in fibroblasts, indicating potential for improving skin elasticity and firmness.
- 03 Twelve triterpene acids from the ethyl acetate-soluble fraction exhibited marked anti-inflammatory effects by inhibiting TPA-induced ear edema in mice.
- 04 Ursolic acid, pomolic acid, corosolic acid, and its methylated derivative demonstrated anti-aging activity by stimulating collagen and hyaluronic acid production.
Transparency
Dusting Analysis
Effective concentrations, such as the 0.5% (w/v) ethanol extract, have demonstrated tangible clinical benefits in various studies, indicating that Eriobotrya Japonica Leaf Extract is incorporated at functional levels rather than for 'dusting' purposes.
The Formula
Formulation
Safety
Safety Profile
Eriobotrya Japonica Leaf Ethanol Extract (EJEE) has shown no irritation in animal alternative tests for skin and eye, and was evaluated as a non-irritant in a reconstructed human epidermis (RHE) model with 98.9 ± 2.0% cell viability. It is classified as 'practically non-toxic' in zebrafish embryogenesis studies (96h LC50 of 189.8 ± 4.5 mg/L). While the Cosmetic Ingredient Review (CIR) Expert Panel has not formally reviewed this ingredient, initial data supports its low irritancy for cosmetic use. However, EWG notes that EWG VERIFIED products require further substantiation for its inclusion.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eriobotrya Japonica Leaf Extract is a valuable, multi-functional ingredient demonstrating significant anti-inflammatory, antioxidant, anti-aging, and skin brightening efficacy with a low irritancy profile, suitable for diverse skin types and product applications.
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References
Sources