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Moumoujus

ERIGERON ANNUUS FLOWER EXTRACT.

Valuable / SKIN CONDITIONING

Erigeron annuus flower extract is a botanical ingredient distinguished by its comprehensive benefits, including potent anti-inflammatory, antioxidant, and cytoprotective activities. It is formulated to soothe irritation, strengthen the skin barrier, and provide defense against environmental stressors, making it particularly suitable for sensitive and compromised skin.

Summary

antioxidant soothing anti-inflammatory skin barrier support anti-itch anti-photoaging cytoprotective astringent

Science

Mechanism of Action

This extract operates via multiple scientific pathways to enhance skin health. It primarily upregulates the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway, bolstering the skin's natural antioxidant defense system and mitigating atopic dermatitis-like symptoms. It actively reduces histamine secretion and significantly decreases the levels of key pro-inflammatory cytokines, including IL-1β, IL-8, IL-6, and IFN-γ, in both human mast cells and keratinocytes. Furthermore, it strengthens the skin barrier by positively influencing genes such as AQP3, FLG, and CASP14. Its anti-photoaging efficacy is linked to inhibiting UVB-induced reactive oxygen species (ROS), MMP-1, and MMP-3 production, while simultaneously promoting type I procollagen formation and activating Nrf2 nuclear translocation and TGF-β1 levels, alongside inhibiting AP-1 and MAPK phosphorylation.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–0.2%
Optimal

N/A

Key findings

  1. 01 In in vitro studies, concentrations of 0.1% and 0.2% demonstrated a significant reduction in histamine secretion and a decrease in pro-inflammatory cytokines (IL-1β, IL-8, IL-6, and IFN-γ) in human mast cells (HMC-1) and keratinocytes (HaCaT). The extract also positively modulated skin barrier genes (AQP3, FLG, CASP14) and interleukins in HaCaT cells, suggesting direct benefits for skin integrity and inflammatory response.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient specific data to determine if this ingredient is commonly associated with dusting or to establish a dusting threshold.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract is typically obtained via cold-water extraction, which implies stability in aqueous environments. One in vitro protein denaturation assay maintained a pH of 7.6 at 25°C for a solution containing the extract; however, this represents assay conditions rather than an established optimal pH range for cosmetic formulation stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessments by CIR, SCCS, or FDA are available for Erigeron annuus flower extract. Oral administration of the extract at 500 and 1000 mg/kg did not induce toxicity in mouse models. An ethyl acetate fraction demonstrated 50% cell viability in HEK293 cells at a concentration of 50 μg/mL, indicating non-toxicity below this level. It is generally considered non-irritating.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Erigeron annuus flower extract is a valuable ingredient for precision skincare, offering scientifically supported anti-inflammatory, antioxidant, and skin barrier-strengthening benefits, making it highly beneficial for sensitive, irritated, and photo-aged skin concerns.

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