Science
Mechanism of Action
The efficacy of Eremanthus Erythropappus Leaf Oil is largely attributed to its α-bisabolol content, which mediates its anti-inflammatory, anti-irritant, antimicrobial, and antioxidant actions. It functions by scavenging free radicals, thereby mitigating oxidative stress. The oil actively targets specific bacteria, including *Staphylococcus aureus* and *Streptococcus pyogenes*, as well as a range of fungi. Additionally, it can act as a skin permeation enhancer, facilitating the deeper delivery of other active ingredients.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Demonstrated antimicrobial activity against *Staphylococcus aureus*, *Streptococcus pyogenes*, and various fungi at concentrations between 0.01 and 0.50 mg/mL. Specifically, it was effective against *Candida albicans* and *Candida tropicalis* at 15 to 125 μg/mL, inhibiting fungal growth.
- 02 Exhibited significant antioxidant capacity, acting as a free radical scavenger with IC50 values of 38.77 to 102.24 μg/mL in DPPH tests and 109.85 to 169.53 μg/mL in reducing power assays.
- 03 Showed anti-inflammatory and antinociceptive effects in mouse models, inhibiting acetic-acid-induced writhing by 10.69% at 200 mg/kg and 27.06% at 400 mg/kg. It also reduced carrageenan-induced paw edema and leucocyte mobilization.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Its primary component, Alpha Bisabolol, demonstrates stability across a broad pH spectrum. To preserve integrity, the oil should be stored tightly sealed and protected from exposure to light and heat.
Synergies
- Functions as a skin permeation enhancer, potentially boosting the efficacy of co-formulated active ingredients by aiding their delivery into deeper skin layers.
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA were found. The ingredient is considered suitable for cosmetic applications, though not for ingestion. An LD50 of 2.90 g/kg in mice for the essential oil suggests relatively low acute oral toxicity. Further clinical studies are indicated to fully establish its safety as a medicinal compound.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eremanthus Erythropappus Leaf Oil is a valuable, multi-functional ingredient providing notable antioxidant, anti-inflammatory, and antimicrobial benefits with low irritancy, making it particularly well-suited for sensitive and oily skin formulations.
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