Science
Mechanism of Action
This extract operates by stimulating the production of critical dermal collagens (I, III, IV, VII) and upregulating hyaluronic acid synthesis (via HAS2), which collectively strengthens the dermal-epidermal junction (DEJ). It also modulates key extracellular matrix glycoproteins such as fibrillin, fibronectin, and versican to improve skin structure and resilience. Furthermore, it exhibits antioxidant activity by modulating glutathione biosynthetic pathways and potentially activating Nrf2, thereby bolstering the skin's defense against oxidative stress.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 In ex vivo explant studies, a 1% concentration significantly increased the production of collagen VII by 115%, collagen I by 119%, and collagen IV by 145% compared to untreated skin, indicating robust dermal support.
- 02 An in vivo efficacy study demonstrated that after 28 days of treatment with a product containing the ingredient, subjects experienced an average reduction in skin roughness by 7%, wrinkle depth by 8%, and volume folds by 9% from baseline. One subject notably showed a 16% visible reduction in nasolabial folds.
- 03 Tef extracts did not affect cell viability and exhibited antioxidant activity in THP-1 monocytes. Specific purified fractions of tef increased cellular glutathione (GSH) levels by up to 234.6% and 194.3% respectively, indicating significant antioxidant modulation.
Transparency
Dusting Analysis
Clinical data indicates significant efficacy at a 1% concentration in ex vivo models, alongside visible improvements in skin parameters from in vivo studies using a formulated product, suggesting effective inclusion levels are achievable.
The Formula
Formulation
Stability
The ingredient is typically produced via enzymatic hydrolysis in water, with protein solubilization occurring at approximately pH 8.0 and precipitation at pH 4.5 during its processing, which may inform optimal handling and formulation pH ranges.
Safety
Safety Profile
While adverse reactions are relatively uncommon, potential instances of skin irritation, redness, or allergic reactions have been noted, warranting a patch test before widespread use. Data concerning its topical application during pregnancy and breastfeeding are currently lacking, advising consultation with a healthcare professional for these individuals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eragrostis Tef Seed Extract is a valuable ingredient, clinically shown to significantly boost collagen production, improve skin texture, and provide antioxidant benefits, making it an excellent choice for anti-aging and skin health formulations.
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References
Sources