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Moumoujus

EPIMEDIUM SAGITTATUM LEAF/STEM EXTRACT.

Insufficient Data CAS - / ANTIOXIDANT, FLAVOURING

Epimedium Sagittatum Leaf/Stem Extract, a botanical ingredient rich in flavonoids like icariin and various polyphenols, exhibits potent antioxidant capabilities. It works to neutralize free radicals and may contribute to reducing various skin alterations. Additionally, it shows potential anti-inflammatory effects and influences cellular processes associated with skin aging.

Summary

Antioxidant Skin Conditioning

Science

Mechanism of Action

This extract functions primarily as an antioxidant by effectively eradicating free radicals and diminishing their reactive capacity within the skin. Its polyphenols are theorized to prevent or reduce skin alterations, while its flavonoids, notably icariin, contribute to potential anti-inflammatory benefits. The extract may also modulate cellular pathways relevant to the aging process.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Specific clinical efficacy data for topical application, including effective dosage ranges in human subjects, is currently unavailable. Therefore, it is not possible to determine if this ingredient is commonly 'dusted' or to establish a relevant dusting threshold for topical formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The active flavonoid compounds within Epimedium extracts have demonstrated stability within a 24-hour period, with relative standard deviations (RSD) ranging from 2.99% to 9.27%. However, processing conditions, particularly heat, are known to influence the overall composition and content of these key active flavonoids.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessments from regulatory bodies like CIR or SCCS have been found for topical cosmetic use. Oral administration studies in rats, utilizing high doses (e.g., above 7.5 g/kg intragastric administration for 13 weeks), suggested potential liver and pancreas injury and dysregulation of metabolic pathways. The no-observed-adverse-effect level (NOAEL) for oral administration in these rat studies was not determined but would be below 7.5 g/kg. While 'no major contraindications' are noted for oral intake, long-term adverse reaction studies are limited, and specific topical safety data for human use is absent.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While EPIMEDIUM SAGITTATUM LEAF/STEM EXTRACT demonstrates promising antioxidant and anti-inflammatory mechanisms, the absence of specific topical clinical efficacy and safety assessments renders the current data insufficient for a definitive rating within precision skincare.

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