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EPIGALLOCATECHIN GALLATYL GLUCOSIDE.

Valuable CAS - / ANTIOXIDANT, SKIN CONDITIONING

EPIGALLOCATECHIN GALLATYL GLUCOSIDE (EGCG-G1) is a bioengineered, stabilized derivative of EGCG, a potent antioxidant from green tea. This modification enhances its stability and delivers multifunctional benefits including antioxidant protection, hydration, and anti-pigmentation effects for comprehensive skin improvement.

Summary

Antioxidant Skin-Conditioning Agent Humectant Soothing Anti-inflammatory Anti-pigmentation Improves Elasticity

Science

Mechanism of Action

This ingredient operates as a powerful antioxidant, primarily by inhibiting oxygen-promoted reactions, which prevents ingredient deterioration and protects skin cells from UV-induced damage and oxidative stress. Its glucose component provides direct hydrating benefits. It actively alleviates DNA damage and inflammation caused by UV radiation, while also inhibiting mitochondrial dysfunction. Furthermore, it enhances skin moisturization and elasticity by modulating genes involved in hyaluronic acid synthesis (HAS) and degradation (HYAL), and key natural moisturizing factor (NMF) components like filaggrin (FLG) and transglutaminase-1 (TGM-1). A notable action includes the reduction of melanin secretion and production, which contributes to its anti-pigmentation efficacy.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

1%

Key findings

  1. 01 Topical formulations containing Epigallocatechin Gallatyl Glucoside have been observed at concentrations up to 1%.
  2. 02 While broad independent clinical studies on EGCG-G1 are limited, one in vivo study specifically demonstrated its significant effects on hyperpigmentation, indicating skin-lightening activity.
  3. 03 The parent molecule, EGCG, has robust data demonstrating improvements in skin elasticity and reduction in the appearance of fine lines and wrinkles in topical applications.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 4.5
0 7 14

Stability

EPIGALLOCATECHIN GALLATYL GLUCOSIDE is a highly water-soluble and stabilized derivative, engineered to overcome the low stability of EGCG, particularly at pH values above 5. Maintaining a formulation pH between 3.5 and 4.5 is crucial for optimal stability, and the inclusion of stabilizers or encapsulation can further prolong its integrity.

Conflicts

  • Metal ions (for the parent EGCG, complexation with citric acid is used to mitigate this)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Independent safety studies specifically on Epigallocatechin Gallatyl Glucoside are currently limited. However, it is considered safe for sensitive skin areas and populations (Teen SAFE, Lip SAFE, Baby SAFE, Eyelid SAFE) by SkinSAFE, and formulated free of many common irritants like fragrance, parabens, and gluten. While its parent compound, EGCG, showed moderate dermal sensitization and irritation in animal studies, EGCG-G1 is a modified, stabilized form designed for improved compatibility.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

EPIGALLOCATECHIN GALLATYL GLUCOSIDE is a valuable, multifunctional ingredient that leverages the powerful benefits of EGCG in a more stable and hydrating form, offering antioxidant, anti-inflammatory, and anti-pigmentation effects for a wide range of skin types.

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