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EPIGALLOCATECHIN GALLATE SAFFLOWERATE.

Valuable / ANTIMICROBIAL

EPIGALLOCATECHIN GALLATE SAFFLOWERATE is a potent derivative of Epigallocatechin Gallate (EGCG), offering significant antioxidant and anti-inflammatory benefits to the skin. It effectively addresses concerns like oxidative stress, UV damage, and excessive oiliness, while enhancing moisturization and promoting a more even skin tone. This ingredient also provides targeted antimicrobial functions, contributing to overall skin health.

Summary

antioxidant anti-inflammatory anticarcinogenic oil-reducing moisturizing pigmentation-reducing photoprotective antimicrobial

Science

Mechanism of Action

The primary active component, Epigallocatechin Gallate (EGCG), acts as a powerful antioxidant, mitigating oxidative stress and repairing diverse forms of skin damage induced by UV radiation. It enhances skin elasticity and improves hydration by upregulating natural moisturizing factor-related genes, including filaggrin, transglutaminase-1, HAS-1, and HAS-2. EGCG also reduces hyperpigmentation by decreasing melanin secretion and production, boosts cellular proliferation, and safeguards keratinocytes from radical-mediated damage. Furthermore, it may offer photoprotective qualities against skin cancer and UV-induced immunosuppression, facilitating DNA repair. The 'Safflowerate' modification specifically contributes antimicrobial properties, assisting in the regulation of microorganisms on the skin.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–2%
Optimal

1%

Key findings

  1. 01 Demonstrated effectiveness in significantly reducing skin oiliness within 7 days of application, based on an in-house evaluation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 3.5 – 4.5
0 7 14

Stability

Epigallocatechin Gallate (EGCG) is inherently unstable, prone to rapid degradation in aqueous solutions through oxidation and autoxidation. Its stability is highly dependent on pH, with rapid degradation occurring above a pH of 5 to 7. Exposure to light, heat, dissolved oxygen, and metal ions also significantly diminishes its purity and efficacy, with substantial degradation observed even at room temperature and up to 85% loss after 1 hour of UV exposure. Optimal stability is achieved within a pH range of 3.5-4.5 and by storing the ingredient at 2-8°C. The incorporation of stabilizers and/or encapsulation techniques is strongly recommended to preserve its integrity and performance.

Conflicts

  • Metal ions (accelerate degradation)
  • Alkaline pH (>5-7)
  • Heat
  • Light

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
6%
Sensitization risk Low

EPIGALLOCATECHIN GALLATE SAFFLOWERATE has not undergone specific review by major regulatory bodies such as CIR, SCCS, or FDA. Information pertaining to general Epigallocatechin Gallate (EGCG) suggests it is not genotoxic. While raw EGCG carries GHS hazard statements for potential allergic skin reactions and serious eye irritation, a cream formulation containing EGCG at 6% concentration exhibited no irritation in albino rabbit skin tests, nor did it induce hypersensitivity reactions or erythema in human patch tests. Concentrations of EGCG at 7% and 10% were, however, noted to potentially lead to toxicity in rabbit studies. The FDA designates *Camellia sinensis* (green tea) as Generally Recognized As Safe (GRAS) for food use, and the CIR Panel has concluded that *Camellia sinensis* leaf extract is safe for cosmetic use up to 0.86% in leave-on products and 1% in rinse-off products.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

EPIGALLOCATECHIN GALLATE SAFFLOWERATE is a valuable, multi-functional active ingredient, offering powerful antioxidant, anti-inflammatory, and oil-regulating properties that benefit a comprehensive range of skin types and concerns, provided its formulation stability is meticulously managed.

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