Science
Mechanism of Action
As a postbiotic, Epidermidibacterium Keratini ferment filtrate delivers beneficial metabolites, notably orotic acid, which plays a role in pyrimidine biosynthesis and the urea cycle. It also produces 1,1′-biuracil, a pyrimidine derivative that has demonstrated anti-aging effects by enhancing gene expression related to longevity in human dermal fibroblasts exposed to UV radiation. This multifaceted action leads to improved skin barrier integrity, increased elasticity, and enhanced dermal density, while fostering a diverse and healthy skin microbiome.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Ferment filtrates are generally known for their broad pH tolerance, offering flexibility for integration into various water-based cosmetic systems.
Safety
Safety Profile
While formal regulatory reviews by bodies such as CIR, SCCS, or FDA are not yet available, a 3-week clinical study observed no adverse effects, including application-site itching, pain, or post-treatment erythema. This initial observation suggests a favorable safety profile for the topical formulation tested.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This postbiotic ingredient demonstrates valuable potential for improving skin barrier function, elasticity, and dermal density, alongside positive microbiome modulation, despite lacking official regulatory review.
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