Science
Mechanism of Action
Eperua Falcata Bark Extract functions as a powerful anti-inflammatory and antioxidant by inhibiting specific proteins that initiate visible redness and by blocking the release of neuropeptides, such as CGRP and SP, which contribute to neurogenic inflammation. Its action extends to strengthening the skin's barrier function, thereby reducing trans-epidermal water loss (TEWL), and neutralizing free radicals to combat damage from environmental aggressors and 'inflamm'aging'—the chronic micro-inflammation that accelerates cellular degeneration and tissue aging.
Research
Clinical Evidence
Medium confidence0.05%
Key findings
- 01 Clinical data indicate that Eperuline visibly improves skin firmness, elasticity, and tonicity, while effectively reducing sagging and signs of age-related chronic micro-inflammation. It further enhances skin barrier integrity, mitigates trans-epidermal water loss, and protects against irritation, erythema, and the damaging effects of UV-A and UV-B radiation.
- 02 Studies, including patent data, demonstrate that Eperua falcata extracts inhibit the spontaneous and induced release of neuropeptides CGRP and SP, making them efficacious in guarding against skin irritation, erythema, inflammation, and adverse effects from UV-A and UV-B exposure within a concentration range of 0.001% to 1% by weight.
Transparency
Dusting Analysis
With an optimal inclusion percentage typically ranging from 0.05% to 0.1% in formulations, Eperua Falcata Bark Extract is incorporated at concentrations that support its proven efficacy without being indicative of 'dusting' for label claims.
The Formula
Formulation
Stability
Although the extraction process may occur in a mildly acidic pH range of 3-4, and subsequent formulation steps might adjust to pH 5-6, a specific optimal pH range for the stability of Eperua Falcata Bark Extract in final cosmetic products is not widely reported.
Conflicts
- When formulating with Vitamin C, it is recommended to apply Vitamin C serums before products containing Eperua Falcata Bark Extract (Eperuline) to minimize potential irritation.
Safety
Safety Profile
Eperua Falcata Bark Extract has not undergone formal review by the Cosmetic Ingredient Review (CIR) Expert Panel or the Scientific Committee on Consumer Safety (SCCS). However, the EWG Skin Deep database indicates low concerns for cancer, allergies, immunotoxicity, and developmental/reproductive toxicity, with fair data availability. Paula's Choice classifies it as generally non-irritating, supporting a low sensitization risk profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eperua Falcata Bark Extract is a valuable, multi-functional ingredient offering significant anti-inflammatory, antioxidant, and skin barrier-strengthening benefits, making it an effective component for addressing signs of aging and environmental stress across all skin types.
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