Science
Mechanism of Action
Entada Phaseoloides Bark/Seed Extract acts primarily through its rich content of polyphenolic antioxidants, which neutralize free radicals and fortify the skin's defenses against environmental aggressors, especially UV radiation. Key active molecules like Entadamide A inhibit inflammation and provide UV absorption, while Phaseoloidin demonstrates potent free-radical scavenging. The extract's soothing properties aid in skin recovery, alleviating dryness and tightness, further enhanced by hydrating fatty acids (oleic, linoleic) and saccharides found in its seeds. In certain concentrations, its saponin content may also contribute to gentle cleansing.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 At concentrations between 1.5% and 4%, the extract has been shown to offer significant soothing benefits for compromised skin, helping to alleviate sensations of dryness and tightness and supporting the skin's recovery from damage. It also enhances the skin's environmental resilience, particularly against UV light, and provides antioxidant, anti-aging, and hydrating effects when formulated in a blend with glycol and water.
- 02 Topical applications of seed pulp formulations demonstrated significant anti-inflammatory activity in animal models, with an ointment showing comparable efficacy to diclofenac, and a paste formulation proving even more effective in reducing paw edema.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Studies indicate Entada Phaseoloides exhibits stability across a broad range of pH values, and remains stable in the presence of minerals, yeast cells, and after UV irradiation. It is frequently supplied as part of a blend containing glycol and water.
Safety
Safety Profile
While acute oral toxicity studies in animals indicate low systemic toxicity via ingestion (LD50 >5000 mg/kg), direct contact with the bark juice has been reported to cause eye irritation and conjunctivitis. Furthermore, the ingredient was found to exhibit detectable genotoxicity. Saponins, a significant component of the extract, are known to have strong hemolytic action on human red blood cells if ingested. No official CIR, SCCS, or FDA status for cosmetic use has been established.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Entada Phaseoloides Bark/Seed Extract is a valuable botanical ingredient, providing robust antioxidant, soothing, and hydrating benefits, making it particularly beneficial for environmentally stressed or impaired skin, though formulation care is advised due to specific safety notes.
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