Science
Mechanism of Action
This extract exerts its effects by scavenging free radicals due to its high flavonoid content. It provides soothing and anti-inflammatory actions through multiple mechanisms: it decreases histamine release from stimulated mast cells and reduces the release of neuro-mediators like Substance P and CGRP from sensory neurons under stress. Furthermore, it mitigates induced inflammation by decreasing prostaglandin E2 production on neutrophils, thus influencing both the nervous and immune systems to address constitutive inflammation.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 In a 28-day study, a face cream containing 2% embelia extract demonstrated significant efficacy, with 95% of volunteers experiencing dry, reactive, and sensitive skin reporting that the product calmed irritation and soothed their skin.
- 02 An in vitro study showed that 50 μg/ml of Embelia concinna extract significantly inhibited induced inflammation by reducing prostaglandin E2 levels in human neutrophils, confirming an anti-inflammatory effect.
- 03 The extract inhibited the release of Substance P and CGRP from sensory neurons in a dose-dependent manner; however, the two lowest tested concentrations did not yield significant results.
Transparency
Dusting Analysis
No data available to suggest this ingredient is commonly dusted or used at ineffective concentrations.
The Formula
Formulation
Stability
While not explicitly detailed, the ingredient's typical preparation with polar solvents and supply in water-glycerin blends suggests good stability in aqueous systems.
Safety
Safety Profile
No specific Cosmetic Ingredient Review (CIR) assessment, Scientific Committee on Consumer Safety (SCCS) opinion, or FDA status was found. EWG Skin Deep rates it with 'Low' concerns for potential health risks, although it notes a lack of scientific literature data. It is generally considered non-irritating to the skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Embelia Concinna Leaf Extract is a valuable botanical ingredient, particularly for sensitive and reactive skin types, offering significant soothing, anti-inflammatory, and antioxidant benefits supported by promising clinical and in-vitro evidence.
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References
Sources