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Moumoujus

ELEPHANTOPUS MOLLIS LEAF EXTRACT.

Valuable CAS - / HUMECTANT

Elephantopus mollis Leaf Extract is a botanical active exhibiting multifaceted benefits, including potent antioxidant and antibacterial properties, as well as an inhibitory effect on melanin synthesis. Traditionally valued for its soothing attributes, it also functions as a humectant, contributing to skin hydration and barrier integrity.

Summary

Antioxidant Humectant Soothing Antibacterial Brightening

Science

Mechanism of Action

This extract exerts its dermatological effects through several pathways. Its antioxidant capacity stems from a rich profile of phytochemicals, including flavonoids, tannins, coumarins, saponins, phenols, and alkaloids, which scavenge free radicals. Anti-melanogenic action is achieved by downregulating microphthalmia-associated transcription factor (MITF) expression, leading to a reduction in tyrosinase (TYR) and tyrosinase-related protein 1 (TRP1), enzymes critical for melanin production. Additionally, it displays direct antibacterial activity against various skin pathogens and contributes to moisture retention as a humectant.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Exhibited significant antioxidant activity in in-vitro assays (DPPH, ABTS, FRAP) with IC50 values ranging from 2.53-4.13 µg/mL for leaf and stem extracts.
  2. 02 Demonstrated antibacterial activity against several human pathogenic bacteria, including Staphylococcus aureus and Streptococcus mutans, with MIC values between 19-156 µg/mL, observed using a disk diffusion method at 50 mg/mL.
  3. 03 Showed an inhibitory effect on melanogenesis in B16 murine melanoma cells by downregulating MITF expression, subsequently reducing tyrosinase and TRP1 expression.

Transparency

Dusting Analysis

Not commonly dusted

No specific data suggests this extract is commonly 'dusted' in cosmetic formulations. The efficacy observed in in-vitro studies does not correlate with a 'dusting' phenomenon typical of highly concentrated, singular active molecules without supporting clinical data.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessments by CIR, SCCS, or FDA are available for Elephantopus mollis leaf extract. Dermal toxicity has not been determined through formal regulatory review, though Incidecoder suggests low irritancy.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Elephantopus mollis Leaf Extract presents a valuable profile of in-vitro benefits for skin health, including antioxidant, antibacterial, and brightening effects, but requires further human clinical studies to validate its in-vivo efficacy and establish optimal usage concentrations.

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