Science
Mechanism of Action
As products of elastin hydrolysis, Elastin Amino Acids serve as fundamental components for synthesizing key skin proteins, including collagen and elastin. They stimulate dermal fibroblasts to increase the production of extracellular matrix (ECM) proteins, directly contributing to the restoration of skin elasticity and overall skin health. The presence of polar amino acids within elastin peptides further aids in retaining water within the skin, thereby boosting hydration. Exogenous elastin peptides, a key component, are also recognized to interact with cellular receptors like the elastin receptor complex (ERC) and Integrin αVβ3, which may play a role in mitigating skin aging and fostering regeneration.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An elastin-like recombinant polypeptide (ELR), applied twice daily for 28 days, significantly enhanced skin elasticity and improved various wrinkle parameters (including count, volume, and area) in healthy women aged 30-55 years.
- 02 A synergistic composition, containing a mixture of amino acids (e.g., glycine, L-proline, L-alanine), copper, and hyaluronic acid, administered four times weekly, led to average improvements of 23.429% in skin elasticity, 14.301% in skin moisture, 7.321% in skin thickness, 12.509% in skin density, and an 8.955% reduction in eye wrinkle depth.
Transparency
Dusting Analysis
No information regarding dusting or typical usage percentages that would lead to 'dusting' has been identified in the available research data.
The Formula
Formulation
Stability
Hydrolyzed elastin, the source of elastin amino acids, is water-soluble. To maintain optimal solubility and dispersion in formulations, it is advisable to keep the pH above 5, as soluble elastin can undergo coacervation (aggregate formation) at pH 2-5 when exposed to temperatures of 50°C. Elastin-like polypeptides (ELPs), related structures, demonstrate general pH stability within the broader range of pH 3 to 11, with certain ELP series showing pH transitions between pH 4 and pH 7. Purified elastin itself exhibits robust resistance to both acid and alkaline hydrolysis even at temperatures up to 100°C.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that α-amino acids, which encompass Elastin Amino Acids derived from hydrolysis, are safe for use in cosmetic applications under current practices and concentrations. No studies have indicated that elastin presents any risks related to irritation, allergic reactions, or photosensitization.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Elastin Amino Acids are a valuable ingredient for improving skin elasticity and hydration by providing essential building blocks and stimulating dermal protein synthesis.
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