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ELAIDOYL TRIPEPTIDE-37.

Valuable CAS - / SKIN CONDITIONING

Elaidoyl Tripeptide-37, also known as Lipospondin, is a synthetic lipo-peptide engineered to enhance skin structure and resilience. It actively promotes collagen and elastin synthesis while mitigating enzymatic degradation, leading to a visibly firmer and smoother complexion. This dual-action ingredient supports skin repair and improves overall elasticity.

Summary

Anti-aging Collagen boosting Elastin boosting Firming Skin elasticity improvement Extracellular matrix support Skin repair Wrinkle reduction

Science

Mechanism of Action

This lipo-peptide operates through a precise dual mechanism. Primarily, it stimulates the Transforming Growth Factor-beta (TGF-β) pathway, which upregulates fibroblast activity to produce essential structural proteins like collagen and elastin. Concurrently, its lipophilic elaidic acid component strategically inhibits and downregulates various metalloproteinase enzymes (MMP-1, MMP-2, MMP-3, and MMP-9) responsible for breaking down collagen and other extracellular matrix components. This combined action boosts skin repair processes, reinforcing the extracellular matrix for improved skin suppleness and firmness.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The lipophilic nature, attributed to its elaidic acid component, may facilitate enhanced skin absorption due to its compatibility with the skin's natural lipid membrane. As a peptide, it is generally susceptible to degradation when exposed to extreme pH conditions, requiring careful formulation within a balanced pH range.

Conflicts

  • Retinoids (due to general peptide instability)
  • Hydroxy acids (due to general peptide instability)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Direct safety assessments from CIR, SCCS, or FDA for Elaidoyl Tripeptide-37 are currently unavailable. However, the CIR Expert Panel has generally deemed related tripeptides and their fatty acyl derivatives safe, typically at concentrations below 10 ppm. Its analog, Palmitoyl Tripeptide-37, is widely regarded as safe and non-irritating for most skin types at standard doses.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Elaidoyl Tripeptide-37 presents as a valuable ingredient for advanced anti-aging formulations, leveraging a clear mechanism to boost collagen and elastin while protecting against their degradation, suitable for all skin types despite limited specific regulatory data.

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