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Moumoujus

ELAEAGNUS GLABRA EXTRACT.

Valuable / SKIN CONDITIONING

Elaeagnus glabra Extract is a botanical ingredient derived from the plant, recognized for its potent antioxidant capabilities and potential to support skin health. Research indicates its ability to combat oxidative stress and maintain tissue integrity, making it a promising component for advanced skincare formulations.

Summary

Skin conditioning Antioxidant Wound healing support Anti-aging (MMP inhibition)

Science

Mechanism of Action

Elaeagnus glabra Extract acts as a multifaceted agent in skin health. It functions as a skin conditioning agent and exhibits notable antioxidant properties, effectively neutralizing free radicals that contribute to skin damage. Beyond this, it has demonstrated the ability to inhibit matrix metalloproteinases (MMP-2 and MMP-9), enzymes crucial for tissue degradation, which suggests a role in preserving skin structure. Drawing from related *Elaeagnus* species, the extract also contributes to wound healing by enhancing human dermal fibroblast migration and upregulating genes associated with tissue repair, such as VEGF-A, HLA-G5, and IL-6. Furthermore, studies on related species indicate potential anti-inflammatory effects, reducing inflammatory markers, and anti-photoaging benefits through decreasing wrinkle formation, restoring collagen, and inhibiting p38 MAPK expression.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An ethanol extract of *Elaeagnus glabra f. oxyphylla* demonstrated significant *in vitro* antioxidant activity, evidenced by IC50 values of 11.35 µg/mL for ABTS and 12.32 µg/mL for DPPH oxidative free radical scavenging, and also inhibited amyloid-β aggregation with an IC50 of 32.01 µg/mL.
  2. 02 A methanol extract of *Elaeagnus glabra* reduced the invasiveness of HT1080 human fibrosarcoma cells *in vitro* in a dose-dependent manner (up to 200 µg/mL without cytotoxicity) by suppressing the activity and expression of MMP-2 and MMP-9.
  3. 03 Studies on related *Elaeagnus* species have shown additional benefits, including improved human dermal fibroblast migration and increased expression of wound healing-related genes (*Elaeagnus angustifolia* at 100 µg/ml), and prevention of UV-mediated photoaging by decreasing wrinkles and microfolds in hairless mice (*Elaeagnus umbellata* fruit extract at 50-200 mg/kg oral doses).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Optimal pH range for stability is not specified. Extracts of Elaeagnus glabra are commonly prepared using solvents such as water, ethanol, or methanol, indicating its versatility for incorporation into both aqueous and alcoholic systems.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Elaeagnus glabra Extract has not undergone specific safety assessments for cosmetic use by major regulatory bodies such as the Cosmetic Ingredient Review (CIR), SCCS, or FDA. No specific hazard identification or irritancy data was found in the available literature, and its irritancy and comedogenicity are currently unknown per INCIDecoder.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Elaeagnus glabra Extract presents itself as a valuable botanical, demonstrating significant *in vitro* antioxidant and tissue-preserving capabilities, making it a compelling candidate for advanced protective and regenerative skincare formulations despite limited direct human topical clinical data.

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