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Moumoujus

EEL SKIN MUCUS EXTRACT.

Insufficient Data / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Eel Skin Mucus Extract is a complex bioactive ingredient derived from the protective secretions of eels. This extract is rich in various biological components, demonstrating notable antimicrobial and antioxidant activities, while also forming a protective barrier on the skin's surface.

Summary

Antimicrobial Antioxidant Skin Protectant

Science

Mechanism of Action

Operating as a sophisticated biological protective layer, Eel Skin Mucus Extract comprises inorganic salts, immunoglobulins, lipids, mucins, and glycoproteins. Its antimicrobial efficacy is driven by peptides that induce bacterial membrane permeabilization, leading to cell lysis, and proteins that disrupt bacterial DNA. Antifungal action involves the formation of pores on fungal cell membranes, effectively inhibiting conidia germination. Furthermore, the extract confers antioxidant benefits by scavenging reactive species.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A methanol extract (1000 µg/mL) showed significant antibacterial activity, inhibiting *E. coli* by 72.46% and *S. aureus* by 68.45% in *in vitro* tests.
  2. 02 An acetone extract (100 mg/mL) exhibited potent antioxidant activity, demonstrating 98.424% scavenging capacity with an IC50 of 36.603 mg/mL.
  3. 03 Further antibacterial efficacy against *S. aureus* was confirmed with an acetone extract at an IC50 of 65.00 ± 3.01 µg/mL.
  4. 04 A methanol extract (100 µl/well) produced a 25.7 ± 0.75 mm inhibition zone against the fungus *Microsporum gypseum*, indicating antifungal properties.
  5. 05 Topical application of a formulated gel (concentration not specified) to rats with bacterial (*Streptococcus pyogenes*, *Staphylococcus aureus*) and fungal (*Microsporum gypseum*, *Candida albicans*) skin infections resulted in complete recovery, paralleling the effects of commercial agents.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is not commonly utilized in mainstream cosmetic formulations. Research primarily focuses on its antimicrobial and antioxidant properties for potential therapeutic applications in skin infection treatment, rather than general cosmetic enhancement or 'dusting' at low, ineffective concentrations.

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 12
0 7 14

Stability

A specific component of eel mucus, AJL-2, has demonstrated stability over a broad pH range, from approximately 3 to 12. Cationic peptides and low-molecular-weight defensive proteins present in fish skin mucus generally exhibit enhanced solubility in mildly acidic solutions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Eel Skin Mucus Extract has not undergone specific review by major cosmetic safety panels such as the Cosmetic Ingredient Review (CIR) Expert Panel or the Scientific Committee on Consumer Safety (SCCS), and there is no reported FDA status for cosmetic use. While one study suggested higher safety for normal cells compared to skin cancer cells, this finding does not constitute a direct safety assessment for general cosmetic application on human skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Eel Skin Mucus Extract demonstrates significant antimicrobial and antioxidant potential in preclinical studies; however, comprehensive human cosmetic safety and efficacy data are currently limited, warranting further investigation for its application in skincare.

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