Science
Mechanism of Action
This extract operates through multiple pathways to enhance skin health. Its robust antioxidant capacity neutralizes free radicals, mitigating oxidative stress and thus addressing signs of aging. It stimulates cell regeneration and aids in improving skin's structural elasticity. Furthermore, Eclipta Prostrata exhibits significant anti-inflammatory actions by reducing redness, suppressing key inflammatory mediators like TNF-α, IL-6 from macrophages, and prostaglandin E2 from human skin cells. Beyond this, it offers moisturizing benefits, supports a healthy skin barrier, and provides antimicrobial properties to combat various skin and scalp concerns.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Completely prevented UVB-induced cell death in human keratinocytes (HaCaT) and mouse fibroblasts (3T3) in vitro, demonstrating significant photoprotective capabilities.
- 02 Significantly attenuated UVB irradiation (30 mJ/cm²) and provided substantial protection against UVB-induced cell death in 3T3 cells in vitro.
- 03 Demonstrated high antioxidant and anti-inflammatory activities in skin cells, with minimal cytotoxicity (less than 10%) against normal fibroblast cells in vitro.
- 04 Enhanced hair growth by increasing the number of hair follicles in the anagenic (growth) phase in male albino rats in vivo.
Transparency
Dusting Analysis
While in vitro studies show significant efficacy at very low concentrations (0.1-0.3 mg/mL), the typically used concentration range in skincare and haircare is 2-5%. This range is common for botanical extracts to achieve broader cosmetic benefits and does not inherently suggest dusting for the full spectrum of reported effects, which extend beyond the specific in vitro test conditions.
The Formula
Formulation
Stability
Optimal stability is maintained when stored in a cool, dry environment between 10-25°C (50-77°F). It generally has a shelf life of 12 months.
Safety
Safety Profile
Eclipta Prostrata Extract is broadly considered safe and non-toxic, with good tolerance across most skin types and non-comedogenic properties. The FDA has recently acknowledged its safety. However, for individuals with known plant sensitivities, a preliminary patch test is recommended due to a low risk of allergic reactions such as redness or itching. In vitro studies observed low cytotoxicity (approximately 6.34-8.76%) in human skin fibroblast cells at concentrations up to 0.3 mg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Eclipta Prostrata Extract is a valuable ingredient for advanced skincare, offering comprehensive benefits including potent antioxidant defense, significant anti-inflammatory action, and cellular regeneration, making it ideal for promoting skin resilience and vitality.
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