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ECHINACEA PURPUREA CALLUS LYSATE.

Valuable / ANTIOXIDANT

Echinacea Purpurea Callus Lysate is a biotechnologically derived ingredient sourced from Echinacea purpurea plant cell cultures. It is engineered to promote skin uniformity and regulate sebum production, making it particularly beneficial for maintaining a balanced, healthy complexion and addressing concerns associated with acne-prone skin.

Summary

Antioxidant Skin conditioning Skin protecting

Science

Mechanism of Action

This ingredient operates on multiple levels to enhance skin health. Primarily, Echinacea Purpurea Callus Lysate has been shown to improve overall skin uniformity and exert a sebum-regulating effect, making it effective for individuals with acne-prone skin. Beyond these targeted actions, it delivers potent antioxidant protection by neutralizing free radicals, thereby safeguarding the skin from environmental stressors and premature aging. It also demonstrates anti-inflammatory properties, assisting in calming irritation and promoting skin healing and repair. Furthermore, its anti-aging potential is realized through the inhibition of key enzymes such as collagenase, elastase, tyrosinase, and hyaluronidase, which are implicated in the degradation of vital skin macromolecules and the visible signs of aging.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A phytocomplex containing Echinacea Purpurea Callus Lysate (EchinAge CROP®-G) demonstrated improvements in skin uniformity and provided a sebum-regulating effect for acne-prone skin.
  2. 02 In an in vitro study, an Echinacea purpurea leaf extract at 50 µg/mL significantly increased the cell viability of normal human dermal fibroblasts.
  3. 03 Echinacea purpurea extracts at 2.5 μL extract/mL promoted scratch closure in HaCaT keratinocyte monolayers, indicating promising wound healing effects.
  4. 04 Topical application of Echinacea purpurea cream and gel formulations for one month in 10 healthy volunteers resulted in increased skin hydration (up to 10.6 AU and 11.4 AU) and reduced wrinkles (by 9.47% and 14.92%). Specific extract concentrations were not provided.

Transparency

Dusting Analysis

Not commonly dusted

While specific concentrations for all clinical outcomes of the Lysate form are not consistently available, a key study references a branded complex (EchinAge CROP®-G) which implies formulation at effective levels. The ingredient offers a wide array of benefits supported by broader Echinacea purpurea extract research.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Optimal stability for general Echinacea purpurea extracts is typically within a pH range of 4.5-6.5. Stability studies on key constituents (alkamides and cichoric acid) suggest cichoric acid content can decrease notably at higher temperatures (25°C and 40°C) compared to cold storage. Alkamides' stability may vary with formulation and the presence of phenolic acids.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Echinacea Purpurea Callus Lysate has not undergone specific review by the Cosmetic Ingredient Review (CIR) Expert Panel. However, related Echinacea Purpurea Extract is generally deemed safe for cosmetic use, being non-irritating and suitable for most skin types, including sensitive skin. Individuals with allergies to plants in the Asteraceae family (e.g., ragweed, chrysanthemums, marigolds) should exercise caution due to potential allergic reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Echinacea Purpurea Callus Lysate is a valuable multi-functional ingredient, offering significant benefits for skin uniformity, sebum regulation, anti-aging, hydration, and protection across diverse skin types with a low risk of irritation.

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