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DULBECCO'S PHOSPHATE BUFFERED SALINE.

Valuable / BUFFERING

Dulbecco's Phosphate Buffered Saline (DPBS) is a carefully balanced salt solution primarily utilized in skincare to stabilize product formulations and support an optimal physiological environment. It functions as a foundational ingredient by regulating pH and providing an isotonic medium, enhancing the efficacy and comfort of other active components.

Summary

Solvent Carrier pH Buffer Isotonic Agent

Science

Mechanism of Action

DPBS primarily acts as a physiological pH regulator and a balanced salt solution. In skincare formulations, its essential role is to maintain the product's pH within a skin-friendly range, ideally between 7.0 and 7.6, and to establish an isotonic environment. This contributes to preserving cellular integrity and viability on the skin's surface, while also serving as an effective solvent and carrier for other cosmetic ingredients.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 7.6
0 7 14

Stability

Liquid DPBS is best stored under refrigeration at 2-8 °C and protected from intense light. While it can withstand short exposures to room temperature, formulations should remain transparent, devoid of any particulate matter or flocculation; avoid using if cloudiness or precipitation is observed.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Phosphate Buffered Saline, a category encompassing DPBS, is safe for use in cosmetics under current practices and concentrations, provided the final product is formulated to be non-irritating. However, it is important to acknowledge that many manufacturers explicitly label DPBS as 'FOR LABORATORY RESEARCH USE ONLY,' advising against its use in diagnostic procedures, human or veterinary applications, or clinical/in vitro procedures. Furthermore, its concentrated powder form is noted as a potential irritant to eyes, the respiratory system, and skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dulbecco's Phosphate Buffered Saline is a valuable ingredient for maintaining optimal product pH and providing an isotonic environment, demonstrating low irritancy potential in diluted cosmetic forms, despite specific manufacturer warnings related to non-cosmetic, laboratory applications.

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