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DRYOPTERIS CRASSIRHIZOMA EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Dryopteris Crassirhizoma Extract, derived from the Asian shield fern, is a multifunctional botanical ingredient. It delivers potent antioxidant and anti-inflammatory benefits, while also demonstrating efficacy in skin brightening and antimicrobial protection.

Summary

Antioxidant Anti-inflammatory Skin brightening Antimicrobial Skin conditioning

Science

Mechanism of Action

This extract operates through several precise mechanisms to enhance skin health. It exhibits robust antioxidant activity by effectively scavenging various free radicals, including DPPH, hydroxyl, and superoxide anion radicals. Its anti-inflammatory properties are attributed to the inhibition of nitric oxide production and the suppression of key inflammatory pathways such as ERK/AP-1 and TBK1/IRF3, helping to calm irritated skin and reduce allergic responses. Furthermore, the extract actively inhibits melanin production and tyrosinase activity, contributing to a more uniform skin tone. Components like phenolic acids, including chlorogenic acid, also impart significant antibacterial effects.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibition of melanogenesis and tyrosinase activity in B16F10 murine melanoma cells by norflavaspidic acid AB.
  2. 02 Significant antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA) by an N-hexane extract.
  3. 03 Inhibition of nitric oxide (NO) production in LPS-stimulated RAW264.7 cells by drycrassirhizomamide A, indicating anti-inflammatory activity.
  4. 04 Strong antioxidant activity, effectively scavenging DPPH, hydroxyl, and superoxide anion radicals, by an acidic polysaccharide fraction (DCP-3).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No GHS classification hazards have been identified for DRYOPTERIS CRASSIRHIZOMA EXTRACT. While oral, dermal, and inhalation toxicity data are not comprehensively determined, an enriched fraction of norflavaspidic acid AB, a component of the extract, exhibited no cytotoxicity in murine HepG2 cells. It is generally recognized as a cosmetic ingredient for skin conditioning, with no specific safety assessments by CIR, SCCS, or FDA as GRAS found.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Dryopteris Crassirhizoma Extract is a valuable botanical ingredient, demonstrating a range of scientifically observed benefits including antioxidant protection, anti-inflammatory action, and skin brightening, making it well-suited for targeted skin concerns.

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