DRACOCEPHALUM MOLDAVICA FLOWER/LEAF/STEM EXTRACT.

Dracocephalum Moldavica Flower/Leaf/Stem Extract exerts its effects by upregulating the expression of critical genes vital for extracellular matrix stability, including COL16A1, COL3A1, COL6A1, and biglycan (BGN). These genes are instrumental in forming robust collagen fibrils, maintaining skin elasticity, and bolstering skin resistance. The extract also directly contributes to enhanced skin hydration and increased dermal density. Rich in flavonoid-glucuronides, such as luteolin- and apigenin-glucuronide, it delivers powerful antioxidant activity by acting as a reducing agent, singlet oxygen quencher, and hydrogen donor, efficiently scavenging DPPH, ABTS, and superoxide anion radicals, alongside demonstrating ferrous ion chelating capabilities. Furthermore, it exhibits anti-inflammatory effects by moderating inducible NO synthase activity, antigenotoxic properties by reducing DNA damage in human dermal fibroblasts (potentially via free radical scavenging and DNA repair intervention), and a pronounced capillary-strengthening effect.