Science
Mechanism of Action
This extract primarily functions as an antioxidant through its rich content of phenolic compounds and flavonoids, which effectively scavenge free radicals, as demonstrated by DPPH, ABTS, and superoxide anion radical-scavenging capacities. Its anti-inflammatory action involves inhibiting nitric oxide production, reducing LPS-induced iNOS expression, and mitigating IL-1β-stimulated MMP13 expression within relevant cell lines, without inducing cytotoxicity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An ethyl acetate extract demonstrated significant antioxidant activity, with an IC50 value at 1.61 mg/mL.
- 02 Various fractions (petroleum ether, ethyl acetate, n-BuOH, water) and isolated pure compounds exhibited robust DPPH, ABTS, and superoxide anion radical-scavenging capabilities.
- 03 A methanol extract demonstrated anti-inflammatory effects by inhibiting nitric oxide production, LPS-induced iNOS, and IL-1β-stimulated MMP13 expression in RAW 264.7 and SW 1353 cell lines, without causing cell death.
Transparency
Dusting Analysis
No specific data on 'dusting' or minimal effective concentrations for cosmetic application are available, making it difficult to assess potential underdosing in formulations.
The Formula
Formulation
Stability
The extract's components exhibit varying polarities, allowing for incorporation into both aqueous and oil-based formulations, as evidenced by extraction processes utilizing solvents like ethyl acetate, ethanol, water, dichloromethane, and methanol. A pH adjustment to 5 during processing suggests potential stability within this range, though a precise optimal pH range for cosmetic formulations is not explicitly defined.
Safety
Safety Profile
Formal safety assessments by major regulatory bodies such as CIR, SCCS, or FDA are not yet detailed. While listed as a skin conditioning agent with low irritancy and comedogenicity, some toxicity data (oral/parenteral, dermal, inhalation) are noted as 'Not determined'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Dracaena Cambodiana Leaf Extract is a valuable ingredient, demonstrating significant in vitro antioxidant and anti-inflammatory benefits with broad skin compatibility, despite an 'unknown' INCIDecoder rating and pending comprehensive regulatory safety review.
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References
Sources