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Moumoujus

DONKEY OIL.

Valuable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Donkey oil is a lipid-rich ingredient offering significant wound-healing acceleration, anti-inflammatory benefits, and vital support for skin homeostasis. Rich in essential fatty acids and natural antioxidants, it provides comprehensive nourishment and soothing properties for the skin.

Summary

Wound Healing Anti-inflammatory Moisturizing Nourishing Soothing Antioxidant Skin Barrier Support Antimicrobial (potential) Skin Softening

Science

Mechanism of Action

Donkey oil maintains skin homeostasis by modulating both host skin cell and microbiota metabolism, specifically influencing aromatic amino acid metabolism and fatty acid biosynthesis. Its profile is rich in unsaturated fatty acids (UFAs) such as oleic acid (32.30%) and linoleic acid (12.90%), alongside vitamin E (8.59 mg/100g fat), which collectively promote neovascularization, extracellular remodeling, migration, and cellular differentiation critical for skin healing. The lipid fraction, akin to human sebum in pH and composition, along with natural collagen and antimicrobial peptides like lysozyme, contributes to its gentle, moisturizing, and barrier-supporting effects.

Research

Clinical Evidence

Medium confidence
Effective range 25–50%
Optimal

50%

Key findings

  1. 01 A 25% concentration significantly accelerated wound closure by 35.22% and reduced inflammatory cell infiltration by 63.77% in a murine incisional wound model. This concentration also preserved skin structural integrity, inhibited inflammatory cytokines, increased VEGF levels, and reduced MMP-9.
  2. 02 A 50% concentration further demonstrated efficacy, accelerating wound closure by 34.33% and reducing inflammatory cell infiltration by 79.00% in a murine incisional wound model. This concentration was identified as optimal for incision-repair, exhibiting similar benefits regarding skin integrity and inflammatory modulation.
  3. 03 Unspecified concentrations applied for 28 days were found to maintain skin homeostasis by modulating both host skin cell and skin microbiota metabolism, particularly through the regulation of aromatic amino acid metabolism and fatty acid biosynthesis.

Transparency

Dusting Analysis

Not commonly dusted

No data is available to suggest that donkey oil is commonly dusted, nor are there established dusting thresholds for this ingredient type.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The stability of donkey oil can be enhanced by incorporating a small amount of natural preservatives, such as vitamin E. It forms homogenous oil-water emulsions when ultrasonicated.

Conflicts

  • Synthetic additives
  • Dilution agents like mineral oil (to preserve potency)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Donkey oil lacks specific safety assessments from the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). However, it is recognized for its 'edible biosafety' and 'nutritional richness'. Scientific evaluations of donkey milk, from which the oil is derived, confirm its safety, microbiological purity, and low allergenic potential, suggesting a favorable safety profile for topical application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Donkey oil is a valuable, lipid-rich ingredient that significantly accelerates wound healing and reduces inflammation, while effectively supporting skin homeostasis across various skin types.

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