Science
Mechanism of Action
Dodoxynol-13 operates on the skin surface by decreasing the interfacial tension between diverse phases. As a surfactant, it enables the thorough mixing of oil-based impurities with water, facilitating their removal during cleansing. Simultaneously, its emulsifying properties create stable blends of otherwise immiscible oil and water components, ensuring the integrity and uniform delivery of product formulations. It can also aid in solubilizing other challenging ingredients within a solvent.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While specific optimal pH parameters are not detailed, Dodoxynol-13 inherently contributes to the stability of emulsions, ensuring product integrity over time due to its emulsifying function.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has consistently affirmed Dodoxynol-13's safety, concluding it is safe as used in cosmetic products, including rinse-off and leave-on formulations, provided it is formulated to be non-irritating. Recent assessments (2023 reaffirmation, 2025 draft report) support this, though the panel is exploring mucous membrane irritation and potential new uses in baby products. The FDA has also approved Octoxynols as indirect food additives. Manufacturers are advised to minimize impurities like heavy metals and ethylene oxide according to FDA limits.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Dodoxynol-13 is a valuable functional ingredient that effectively stabilizes formulations and aids in gentle cleansing by expertly blending oil and water components.
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References
Sources