DITRIMETHYLOLPROPANE TETRASTEARATE.

While DITRIMETHYLOLPROPANE TETRASTEARATE itself has not been directly reviewed by CIR, analogous compounds like Pentaerythrityl Tetraesters are considered safe for cosmetic application. Specifically, PEG-150 Pentaerythrityl Tetrastearate, sharing structural similarities, has been deemed safe at concentrations up to 5% in rinse-off products and 1.8% in leave-on formulations. Its large molecular size suggests minimal skin penetration, and human repeated insult patch tests at high concentrations (undiluted and 25% aqueous solution) showed no irritation or sensitization. EWG Skin Deep rates this ingredient with low concern across various toxicity categories. It is recognized within the FDA Global Substance Registration System (GSRS).