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Moumoujus

DISTYLIUM RACEMOSUM EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Distylium Racemosum Extract is a botanical active characterized by its broad spectrum of benefits for skin health. It demonstrates potent anti-inflammatory and antioxidant capabilities, while also offering targeted support for skin brightening and elasticity through enzymatic modulation.

Summary

Antioxidant Anti-inflammatory Soothing Skin Brightening Anti-aging Skin Conditioning

Science

Mechanism of Action

The extract operates via several biological pathways: it effectively inhibits phosphodiesterase 4 activity and suppresses specific inflammatory signaling cascades, thereby reducing cellular inflammation. Its antioxidant capacity neutralizes damaging free radicals. Furthermore, it actively inhibits tyrosinase, a key enzyme in melanin production, suggesting a role in skin brightening. Inhibition of elastase contributes to maintaining skin elasticity, and the extract also influences gene expression to mitigate lipid accumulation and fibrosis.

Research

Clinical Evidence

Medium confidence
Effective range 0.0025–0.05%
Optimal

N/A

Key findings

  1. 01 Inhibited phosphodiesterase 4 activity in vitro and suppressed inflammatory signaling, concurrently inhibiting tyrosinase, elastase, and ribonuclease H activities.
  2. 02 Significantly reduced intracellular triglyceride accumulation in a dose-dependent manner in palmitic acid-induced AML12 hepatocytes.
  3. 03 Markedly inhibited nitric oxide (NO) production by approximately 85% and suppressed iNOS protein expression by approximately 90% in LPS-stimulated RAW 264.7 macrophages, through HO-1 induction.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%

Clinical studies indicate significant biological activity at concentrations as low as 0.0025% up to 0.05%, suggesting efficacy can be achieved without excessively high inclusion rates that might suggest 'dusting'.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract's components exhibit solubility in both aqueous and organic solvents. While a precise optimal pH range for stability is not explicitly defined, the general stability of botanical extracts is known to be susceptible to environmental factors such as pH fluctuations, temperature variations, light exposure, and oxidation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Formal safety reviews by authoritative bodies like CIR or SCCS are not yet available. While its FDA status for cosmetic use is unspecified, no GHS hazard statements have been identified, and preliminary data suggests low irritancy with no determined oral, dermal, or inhalation toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Distylium Racemosum Extract is a valuable, multifunctional botanical offering significant anti-inflammatory, antioxidant, and enzymatic modulating benefits, making it highly suitable for targeted precision skincare solutions.

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