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DISODIUM TETRAMETHYLHEXADECENYL SUCCINOYL CYSTEINE.

Valuable CAS 1869058-84-3 / REDUCING, SKIN CONDITIONING, SKIN PROTECTING

DISODIUM TETRAMETHYLHEXADECENYL SUCCINOYL CYSTEINE, also known as TSC or SIG1273, is an innovative isoprenylcysteine small molecule engineered to modulate inflammatory pathways and bolster the skin's natural barrier. This 'super-lipid' offers comprehensive benefits, acting as a potent antioxidant, an effective anti-bacterial agent, and a soothing compound for enhanced skin resilience.

Summary

Anti-inflammatory Antioxidant Anti-bacterial Barrier Support Anti-aging Hydrating Soothing

Science

Mechanism of Action

This ingredient functions by down-modulating inflammatory signaling pathways within various cellular types, including keratinocytes, peripheral blood mononuclear cells, and endothelial cells. It exhibits robust radical scavenging antioxidant capabilities, actively blocking TPA and UVB-induced cytokine production to mitigate inflammation. Furthermore, it inhibits the overproduction of specific interleukins (IL-4, IL-17, IL-6, IL-8) involved in immune responses, while its anti-bacterial properties inhibit *Streptococcus pyogenes* growth. This multifaceted action promotes restoration of the skin’s natural barrier, fostering a healthier, more resilient dermal ecosystem.

Research

Clinical Evidence

High confidence
Effective range 0.25–0.5%
Optimal

N/A

Key findings

  1. 01 Clinical assessment of a 0.25% SIG1273 cream demonstrated significant improvements in key aesthetic and physiological parameters. Participants experienced noticeable reductions in the appearance of fine lines and coarse wrinkles, enhanced skin radiance and luminosity, diminished pore size, improved texture and smoothness, increased hydration levels, and augmented skin firmness. The formulation was observed to be well tolerated by the skin.
  2. 02 In a pilot study, a 0.5% TSC formulation, when combined with 0.2% tretinoin, elicited a milder dermal response and a faster reduction in both dryness and erythema. This outcome was superior to that observed with 0.2% tretinoin alone and a comparable formulation containing 0.5% QFC + 0.2% tretinoin, highlighting its irritation-mitigating properties.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges for stability have not been precisely identified in the available data. However, this ingredient has demonstrated utility in formulations with tretinoin, where it effectively reduces common irritation associated with retinoid use.

Synergies

  • Tretinoin (for irritation reduction)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

DISODIUM TETRAMETHYLHEXADECENYL SUCCINOYL CYSTEINE (SIG1273) is registered within the FDA Global Substance Registration System (GSRS) and has been noted on priority lists for evaluation by the Cosmetic Ingredient Review (CIR) Expert Panel. As of current information, a final safety assessment conclusion from the CIR has not been published. Its inclusion in various cosmetic products has been reported to the FDA's Voluntary Cosmetics Reporting Program (VCRP).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

DISODIUM TETRAMETHYLHEXADECENYL SUCCINOYL CYSTEINE is a valuable multi-functional ingredient demonstrating significant anti-inflammatory, antioxidant, and barrier-restoring benefits, with proven efficacy in improving skin appearance and reducing irritation.

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